Reducing Rates of Severe Hypoglycemia in a Population-Based Cohort of Children and Adolescents With Type 1 Diabetes Over the Decade 2000-2009

被引：63

作者：

O'Connell, Susan M. ^{[1
,2
]}

Cooper, Matthew N. ^{[2
]}

Bulsara, Max K. ^{[3
]}

Davis, Elizabeth A. ^{[1
,2
]}

Jones, Timothy W. ^{[1
,2
]}

机构：

[1] Princess Margaret Hosp Children, Dept Endocrinol & Diabet, Perth, WA, Australia

[2] Univ Western Australia, Diabet & Endocrinol Div, Telethon Inst Child Hlth Res, Ctr Child Hlth Res, Perth, WA 6009, Australia

[3] Univ Notre Dame, Dept Biostat, Inst Hlth & Rehabil Res, Fremantle, WA, Australia

来源：

DIABETES CARE | 2011年 / 34卷 / 11期

关键词：

CARE; IDDM;

D O I：

10.2337/dc11-0748

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-To examine rates of severe hypoglycemia (SH) in a large population-based cohort of children with type 1 diabetes and relationships to HbA(1c). RESEARCH DESIGN AND METHODS-Data from 1,683 children (mean [SD] age at diagnosis 10.5 [4.2]; range 1-18 years) from 2000 to 2009 were analyzed from the Western Australian Children's Diabetes Database. Rates of SH were related to HbA(1c) using negative binomial regression. RESULTS-A total of 7,378 patient-years of data and 780 SH events were recorded. The rate of SH per 100 patient-years peaked at 17.3 in 2001 and then declined from 2004 to a nadir of 5.8 in 2006. HbA(1c) <7% was not associated with higher risk of SH (incidence rate ratio 1.2 [95% CI 0.9-1.6], P = 0.29) compared with HbA(1c) of 8-9%. CONCLUSIONS-In a sample of youth with type 1 diabetes, there has been a decrease in rates of SH and a weaker relationship with glycemic control than previously observed.

引用

页码：2379 / 2380

页数：2

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