Fas counter-attack - the best form of tumor defense?

被引:56
作者
O'Connell, J [1 ]
Bennett, MW
O'Sullivan, GC
Collins, JK
Shanahan, F
机构
[1] Natl Univ Ireland Univ Coll Cork, Univ Hosp, Dept Med, Cork, Ireland
[2] Natl Univ Ireland Univ Coll Cork, Mercy Hosp, Dept Surg, Cork, Ireland
关键词
D O I
10.1038/6477
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
New in vivo evidence confirms that tumor-expressed Fas ligand impairs immune responses to cancer by inducing apoptosis of anti-tumor immune effector cells.
引用
收藏
页码:267 / 268
页数:2
相关论文
共 13 条
  • [1] Bennett MW, 1998, J IMMUNOL, V160, P5669
  • [2] Cardi G, 1998, CANCER RES, V58, P2078
  • [3] Regulation of the proinflammatory effects of Fas ligand (CD95L)
    Chen, JJ
    Sun, YN
    Nabel, GJ
    [J]. SCIENCE, 1998, 282 (5394) : 1714 - 1717
  • [4] Daniel PT, 1997, J IMMUNOL, V159, P3808
  • [5] CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance
    Griffith, TS
    Yu, XH
    Herndon, JM
    Green, DR
    Ferguson, TA
    [J]. IMMUNITY, 1996, 5 (01) : 7 - 16
  • [6] Melanoma cell expression of Fas(Apo-1/CD95) ligand: Implications for tumor immune escape
    Hahne, M
    Rimoldi, D
    Schroter, M
    Romero, P
    Schreier, M
    French, LE
    Schneider, P
    Bornand, T
    Fontana, A
    Lienard, D
    Cerottini, JC
    Tschopp, J
    [J]. SCIENCE, 1996, 274 (5291) : 1363 - 1366
  • [7] Depletion of the natural killer cell population in the peritoneum by AK-5 tumor cells overexpressing Fas-ligand: A mechanism of immune evasion
    Khar, A
    Varalakshmi, C
    Pardhasaradhi, BVV
    Ali, AM
    Kumari, AL
    [J]. CELLULAR IMMUNOLOGY, 1998, 189 (02) : 85 - 91
  • [8] Prolonged survival of rat liver allografts transfected with Fas ligand-expressing plasmid
    Li, XK
    Okuyama, T
    Tamura, A
    Enosawa, S
    Kaneda, Y
    Takahara, S
    Funashima, N
    Yamada, M
    Amemiya, H
    Suzuki, S
    [J]. TRANSPLANTATION, 1998, 66 (11) : 1416 - 1423
  • [9] Maeda A, 1998, BRIT J DERMATOL, V139, P198
  • [10] O'Connell J, 1998, J PATHOL, V186, P240