Targeting the canonical Wnt/-catenin pathway in hematological malignancies

被引：122

作者：

Ashihara, Eishi ^{[1
]}

Takada, Tetsuya ^{[1
]}

Maekawa, Taira ^{[2
]}

机构：

[1] Kyoto Pharmaceut Univ, Dept Clin & Translat Physiol, Kyoto 607, Japan

[2] Kyoto Univ Hosp, Dept Transfus Med & Cell Therapy, Kyoto 606, Japan

来源：

CANCER SCIENCE | 2015年 / 106卷 / 06期

关键词：

canonical Wnt pathway; hematological malignancies; high-throughput screening; small molecule inhibitors; beta-Catenin; ACUTE MYELOID-LEUKEMIA; HEMATOPOIETIC STEM-CELL; TANDEM DUPLICATION MUTATIONS; CHRONIC LYMPHOCYTIC-LEUKEMIA; SMALL-MOLECULE INHIBITORS; BETA-CATENIN; SIGNALING PATHWAY; GENE-EXPRESSION; CONSTITUTIVE ACTIVATION; KINASE INHIBITORS;

D O I：

10.1111/cas.12655

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The canonical Wnt/-catenin pathway plays an important role in different developmental processes through the regulation of stem cell functions. In the activation of the canonical Wnt/-catenin pathway, -catenin protein is imported into the nucleus and activates transcription of target genes including cyclin D1 and c-myc. Aberrant activation of the Wnt/-catenin pathway contributes to carcinogenesis and malignant behaviors, and Wnt signaling is essential for the maintenance of cancer stem cells. The canonical Wnt/-catenin pathway has been investigated extensively as a target in cancer treatment and several specific inhibitors of this signaling pathway have been identified through high-throughput screening. In this review, the significance of the canonical Wnt/-catenin pathway in hematological carcinogenesis and screening methods for specific inhibitors are discussed.

引用

页码：665 / 671

页数：7

共 72 条

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