A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice

被引：61

作者：

Herron, BJ

Liddell, RA

Parker, A

Grant, S

Kinne, J

Fisher, JK

Siracusa, LD

机构：

[1] New York State Dept Hlth, Wadsworth Ctr, Genom Inst, Albany, NY 12180 USA

[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

NATURE GENETICS | 2005年 / 37卷 / 11期

关键词：

D O I：

10.1038/ng1652

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Stratifin (Sfn, also called 14-3-3 sigma) is highly expressed in differentiating epidermis and mediates cell cycle arrest. Sfn is repressed in cancer, but its function during development is uncharacterized. We identified an insertion mutation in the gene Sfn in repeated epilation (Er) mutant mice by positional cloning. Er/+ mice expressed a truncated Sfn protein, which probably contributes to the defects in Er/Er and Er/+ epidermis and to cancer development in Er/+ mice.

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页码：1210 / 1212

页数：3

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