Dopamine in disturbances of food and drug motivated behavior: A case of homology?

被引：42

作者：

Di Chiara, G

机构：

[1] Univ Cagliari, Dept Toxicol, I-09124 Cagliari, Italy

[2] Univ Cagliari, Ctr Excellence Studies Dependence, I-09124 Cagliari, Italy

来源：

PHYSIOLOGY & BEHAVIOR | 2005年 / 86卷 / 1-2期

关键词：

addiction; dopamine; feeding; motivation; nucleus accumbens; reward;

D O I：

10.1016/j.physbeh.2005.06.020

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Highly palatable food and drugs of abuse share the ability to stimulate dopamine transmission in the shell of the nucleus accumbens. However, while in the case of food this property is adaptively regulated in a negative fashion upon repeated exposure to the reward, no such regulation is operative towards drugs of abuse. Dysadaptive stimulation of dopamine transmission in the accumbens shell is assigned an important role in the compulsive motivation for drugs typical of drug addiction. It is speculated that disturbances of feeding behavior are related to loss of adaptive regulation of food-stimulated release of dopamine in the shell of the accumbens. (c) 2005 Published by Elsevier Inc.

引用

页码：9 / 10

页数：2

共 8 条

[1] Differential expression of motivational stimulus properties by dopamine in nucleus accumbens shell versus core and prefrontal cortex [J].