New Strategies in Neuroprotection and Neurorepair

被引：15

作者：

Antonelli, Marta C. ^{[1
]}

Guillemin, Gilles J. ^{[2
]}

Raisman-Vozari, Rita ^{[3
]}

Del-Bel, Elaine A. ^{[4
]}

Aschner, Michael ^{[5
,6
,7
]}

Collins, Michael A. ^{[8
]}

Tizabi, Yousef ^{[9
]}

Moratalla, Rosario ^{[10
]}

West, Adrian K. ^{[11
]}

机构：

[1] Univ Buenos Aires, Inst Quim & Fisicoquim Biol UBA CONICET, Fac Farm & Bioquim, RA-1053 Buenos Aires, DF, Argentina

[2] Univ New S Wales, Sch Med Sci, Neuroinflammat Grp, Sydney, NSW, Australia

[3] Hop La Pitie Salpetriere, INSERM, CRICM, UMRS 975, F-75651 Paris, France

[4] FORP, Dept Physiol, Sch Odontol, Ribeirao Preto, Brazil

[5] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA

[6] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA

[7] Vanderbilt Univ, Med Ctr, Kennedy Ctr Res Human Dev, Nashville, TN 37232 USA

[8] Loyola Univ, Sch Med, Dept Mol Pharmacol & Therapeut, Maywood, IL 60153 USA

[9] Howard Univ, Dept Pharmacol, Coll Med, Washington, DC 20059 USA

[10] CSIC, Inst Cajal, Consejo Super Invest Cient, Madrid 28002, Spain

[11] Univ Tasmania, Menzies Res Inst, Hobart, Tas 7001, Australia

来源：

NEUROTOXICITY RESEARCH | 2012年 / 21卷 / 01期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Neuroprotection; Oxidative stress; Metallothionein; Glia; Cannabinoids; Alcohol; MICROGLIAL ACTIVATION; CANNABINOID RECEPTORS; COGNITIVE DECLINE; RAT-BRAIN; METALLOTHIONEIN; EXPRESSION; NEUROTOXICITY; TRANSPORTER; GLUTATHIONE; DEMENTIA;

D O I：

10.1007/s12640-011-9265-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

There are currently few clinical strategies in place, which provide effective neuroprotection and repair, despite an intense international effort over the past decades. One possible explanation for this is that a deeper understanding is required of how endogenous mechanisms act to confer neuroprotection. This mini-review reports the proceedings of a recent workshop "Neuroprotection and Neurorepair: New Strategies" (Iguazu Falls, Misiones, Argentina, April 11-13, 2011, Satellite Symposium of the V Neurotoxicity Society Meeting, 2011) in which four areas of active research were identified to have the potential to generate new insights into this field. Topics discussed were (i) metallothionein and other multipotent neuroprotective molecules; (ii) oxidative stress and their signal mediated pathways in neuroregeneration; (iii) neurotoxins in glial cells, and (iv) drugs of abuse with neuroprotective effects.

引用

页码：49 / 56

页数：8

共 50 条

[1]

Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8-hydroxyguanine levels in substantia nigra [J].