Anti-AIDS agents.: 46.: Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives

被引：112

作者：

Ishida, J

Wang, HK

Oyama, M

Cosentino, ML

Hu, CQ

Lee, KH ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[2] Biotech Res Labs Inc, Gaithersburg, MD 20877 USA

[3] Shanghai Med Univ, Sch Pharm, Shanghai 200032, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 07期

关键词：

D O I：

10.1021/np0101189

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Matairesinol (1) and harman (5), identified from Symplocos setchuensis, were found to inhibit HIV replication in H9 lymphocyte cells. Anti-HIV evaluation of 28 derivatives of 5 revealed that compound 19 showed potent activity with EC50 and therapeutic index values of 0.037 muM and 210, respectively.

引用

页码：958 / 960

页数：3

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