IMGT, the international ImMunoGeneTics database

被引：368

作者：

Lefranc, MP

Giudicelli, V

Ginestoux, C

Bodmer, J

Müller, W

Bontrop, R

Lemaitre, M

Malik, A

Barbié, V

Chaume, D

机构：

[1] Univ Montpellier 2, Immunogenet Mol Lab, CNRS, UPR 1142,IGH, F-34396 Montpellier 5, France

[2] Imperial Canc Res Fund, Oxford, England

[3] IFG, Cologne, Germany

[4] BPRC, Rijswijk, Netherlands

[5] EUROGENTEC SA, Seraing, Belgium

[6] EMBL Outstn EBI, Hinxton, England

[7] CNUSC, Montpellier, France

来源：

NUCLEIC ACIDS RESEARCH | 1999年 / 27卷 / 01期

关键词：

D O I：

10.1093/nar/27.1.209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IMGT, the international ImMunoGeneTics database (http://imgt.cnusc.fr:8104), is a high-quality integrated database specialising in Immunoglobulins (Ig), T cell Receptors (TcR) and Major Histocompatibility Complex (MHC) molecules of all vertebrate species, created in 1989 by Marie-Paule Lefranc, Universite Montpellier II, CNRS, Montpellier, France (lefranc@ligm.igh.cnrs.fr). IMGT comprises three databases: LIGM-DB, a comprehensive database of Ig and TcR, MHC/HLA-DB, and PRIMER-DB (the last two in development); a tool, IMGT/DNAPLOT, developed for sequence analysis and alignments; and expertised data based on the IMGT scientific chart, the IMGT repertoire. By its high quality and its easy data distribution, IMGT has important implications in medical research (repertoire in autoimmune diseases, AIDS, leukemias, lymphomas), therapeutic approaches (antibody engineering), genome diversity and genome evolution studies. IMGT is freely available at http://imgt.cnusc.fr:8104.

引用

页码：209 / 212

页数：4

共 16 条

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