Radial glia cells are candidate stem cells of ependymoma

被引：631

作者：

Taylor, MD

Poppleton, H

Fuller, C

Su, XP

Liu, YX

Jensen, P

Magdaleno, S

Dalton, J

Calabrese, C

Board, J

MacDonald, T

Rutka, J

Guha, A

Gajjar, A

Curran, T

Gilbertson, RJ

机构：

[1] St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Hartwell Ctr Bioinformat & Biotechnol, Memphis, TN 38105 USA

[4] Childrens Natl Med Ctr, Dept Pediat Hematol & Oncol, Washington, DC 20010 USA

[5] Hosp Sick Children, Div Neurosurg, Toronto, ON M5G 1X8, Canada

[6] Hosp Sick Children, Arthur & Sonia Labatt Brain Tumor Res Ctr, Toronto, ON M5G 1X8, Canada

[7] Toronto Western Hosp, Div Neurosurg, Toronto, ON M5T 2S8, Canada

[8] St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA

来源：

CANCER CELL | 2005年 / 8卷 / 04期

关键词：

D O I：

10.1016/j.ccr.2005.09.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumors of the same histologic type often comprise clinically and molecularly distinct subgroups; however, the etiology of these subgroups is unknown. Here, we report that histologically identical, but genetically distinct, ependymomas exhibit patterns of gene expression that recapitulate those of radial glia cells in the corresponding region of the central nervous system. Cancer stem cells isolated from ependymomas displayed a radial glia phenotype and formed tumors when orthotopically transplanted in mice. These findings identify restricted populations of radial glia cells as candidate stem cells of the different subgroups of ependymoma, and they support. a general hypothesis that subgroups of the same histologic tumor type are generated by different populations of progenitor cells in the tissues of origin.

引用

页码：323 / 335

页数：13

共 55 条

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