Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic

被引：188

作者：

Williams, NA ^{[1
]}

Hirst, TR ^{[1
]}

Nashar, TO ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Pathol & Microbiol, Bristol BS8 1TD, Avon, England

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0167-5699(98)01397-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cholera toxin and ifs close relative, Escherichia coli heat-labile enterotoxin, ave potent immunogens and mucosal adjuvents. The recent findings that their B subunits can promote tolerance highlights the complexity of their interactions with the immune system. Here, Neil Williams and colleagues review the mechanisms by which these molecules modulate leukocyte populations and seek to explain the paradox.

引用

页码：95 / 101

页数：7

共 64 条

[1] A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes [J].

Bergerot, I ;

Ploix, C ;

Petersen, J ;

Moulin, V ;

Rask, C ;

Fabien, N ;

Lindblad, M ;

Mayer, A ;

Czerkinsky, C ;

Holmgren, J ;

Thivolet, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (09) :4610-4614

[2]

BOWEN JC, 1994, IMMUNOLOGY, V81, P338

[3]

BROMANDER A, 1991, J IMMUNOL, V146, P2908

[4]

CHIOCCHIA G, 1990, J IMMUNOL, V145, P519

[5]

CLARKE CJ, 1991, IMMUNOLOGY, V72, P323

[6] ADJUVANT ACTIVITY OF ESCHERICHIA-COLI HEAT-LABILE ENTERO-TOXIN AND EFFECT ON THE INDUCTION OF ORAL TOLERANCE IN MICE TO UNRELATED PROTEIN ANTIGENS [J].

CLEMENTS, JD ;

HARTZOG, NM ;

LYON, FL .

VACCINE, 1988, 6 (03) :269-277

[7] TARGETING AUTOANTIGEN TO B-CELLS PREVENTS THE INDUCTION OF A CELL-MEDIATED AUTOIMMUNE-DISEASE IN RATS [J].

DAY, MJ ;

TSE, AGD ;

PUKLAVEC, M ;

SIMMONDS, SJ ;

MASON, DW .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (03) :655-659

[8]

de Haan L, 1998, EUR J IMMUNOL, V28, P1243, DOI 10.1002/(SICI)1521-4141(199804)28:04<1243::AID-IMMU1243>3.0.CO

[9]

2-E

[10] Mutants of the Escherichia coli heat-labile enterotoxin with reduced ADP-ribosylation activity or no activity retain the immunogenic properties of the native holotoxin [J].

DeHaan, L ;

Verweij, WR ;

Feil, IK ;

Lijnema, TH ;

Hol, WGJ ;

Agsteribbe, E ;

Wilschut, J .

INFECTION AND IMMUNITY, 1996, 64 (12) :5413-5416

← 1 2 3 4 5 6 7 →