Conformationally restricted analogs of Combretastatin A-4 derived from SU5416

被引：35

作者：

Li, PK

Xiao, ZL

Hu, ZG

Pandit, B

Sun, YJ

Sackett, DL

Werbovetz, K

Lewis, A

Johnsamuel, J

机构：

[1] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA

[2] NICHHD, Lab Integrat & Med Biophys, NIH, Bethesda, MD 20892 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 24期

关键词：

D O I：

10.1016/j.bmcl.2005.09.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of compounds originally derived from the vascular endothelial growth factor receptor tyrosine kinase inhibitor, SU5416, was synthesized and evaluated. The most potent compound in this series, compound 7, structurally resembles the potent anti -microtubule agent Combretastatin A-4, inhibited tubulin polymerization, and showed potent growth inhibitory activities on both prostate and breast cancer lines with IC50 values in low to subnanomolar range. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：5382 / 5385

页数：4

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