Sirtuins as regulators of metabolism and healthspan

被引：1576

作者：

Houtkooper, Riekelt H. ^{[1
,2
]}

Pirinen, Eija ^{[1
,3
]}

Auwerx, Johan ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Integrat & Syst Physiol, Lausanne, Switzerland

[2] Univ Amsterdam, Acad Med Ctr, Lab Genet Metab Dis, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Eastern Finland, AI Virtanen Inst Mol Sci, Bioctr Kuopio, Kuopio, Finland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 04期

基金：

瑞士国家科学基金会; 芬兰科学院;

关键词：

RECEPTOR-GAMMA COACTIVATOR-1-ALPHA; FATTY-ACID OXIDATION; SMALL-MOLECULE ACTIVATORS; CALORIE RESTRICTION; LIFE-SPAN; SKELETAL-MUSCLE; SACCHAROMYCES-CEREVISIAE; INSULIN-SECRETION; MAMMALIAN SIR2; DEACETYLASE ACTIVITY;

D O I：

10.1038/nrm3293

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1-SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in different cellular compartments: they deacetylate histones and several transcriptional regulators in the nucleus, but also specific proteins in other cellular compartments, such as in the cytoplasm and in mitochondria. As a consequence, sirtuins regulate fat and glucose metabolism in response to physiological changes in energy levels, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan.

引用

页码：225 / 238

页数：14

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