Interaction of acidic poly-amino acids with octacalcium phosphate

被引：39

作者：

Bigi, A ^{[1
]}

Boanini, E ^{[1
]}

Bracci, B ^{[1
]}

Falini, G ^{[1
]}

Rubini, K ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2003年 / 95卷 / 04期

关键词：

octacalcium phosphate; hydroxyapatite; poly-L-aspartate; poly-L-glutamate; X-ray diffraction;

D O I：

10.1016/S0162-0134(03)00127-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Octacalcium phosphate (OCP) hydrolysis into hydroxyapatite (HA) has been investigated in aqueous solutions at different concentrations Of poly-(L)-aspartate (PASP) and poly-(L)-glutamate (PGLU). In the absence of the polyelectrolytes, the transformation of OCP into HA is complete in 48 h. Both poly-(L)-aspartate and poly-(L)-glutamate inhibit OCP hydrolysis. However, PGLU displays a greater inhibiting effect, as a result of the different extent of phase transformation obtained at the same polyelectrolyte concentration. The inhibition takes place through polyelectrolyte adsorption on the (100) face of OCP crystals, which prevents the splitting of OCP crystals along their c-axis and the transformation into the final very long, needle-like, apatitic crystals. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：291 / 296

页数：6

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