The structure and energetics of helix formation by short templated peptides in aqueous solution .2. Characterization of the helical structure of Ac-Hel(1)-Ala(6)-OH

被引：44

作者：

Kemp, DS

Allen, TJ

Oslick, SL

Boyd, JG

机构：

[1] Department of Chemistry, Massachusetts Inst. of Technology, Cambridge

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1996年 / 118卷 / 18期

关键词：

D O I：

10.1021/ja9529100

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Analysis of NOE cross-peaks in H-1 NMR ROESY spectra of Ac-Hel(1)-Ala(6)-OH in water and in water-trifluoroethanol mixtures demonstrates that the template Ac-Hell initiates an alpha-helix in a linked hexa-Ala peptide. Other NMR parameters and circular dichroism spectra are consistent with the presence of an alpha-helix, frayed at the C-terminus. Effects of NaCl, urea, temperature, and trifluoroethanol on the stability of a short alanine helix are reported.

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页码：4240 / 4248

页数：9

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