Antihistaminic flavones and aliphatic glycosides from Mentha spicata

被引：108

作者：

Yamamura, S ^{[1
]}

Ozawa, K ^{[1
]}

Ohtani, K ^{[1
]}

Kasai, R ^{[1
]}

Yamasaki, K ^{[1
]}

机构：

[1] Hiroshima Univ, Sch Med, Inst Pharmaceut Sci, Minami Ku, Hiroshima 734, Japan

来源：

PHYTOCHEMISTRY | 1998年 / 48卷 / 01期

关键词：

Mentha spicata; Labiatae; flavonoids; aliphatic glucosides; antiallergic; exocytosis inhibitor;

D O I：

10.1016/S0031-9422(97)01112-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The ethyl acetate soluble portion of the methanol extract of Mentha spicata var. crispa showed inhibitory activity on exocytosis in antigen-stimulated rat basophils. The bioassay-guided separation of the components of this fraction afforded 13 compounds. The chemical structures were elucidated to be four known flavonoids, three new and five known glucosides of lower alcohols and rosmarinic acid by means of chemical and spectroscopic evidences. Among them, three compounds showed biological activity. From the non-active 1-butanol soluble portion of the methanol extract, four new and two known structurally related glycosides were isolated and characterized. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：131 / 136

页数：6

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