A set of experiments on neutron and x-ray generation was performed on the S-300 facility for the last few months. The S-300 facility is a pulse generator with electric current achieving 3.5 MA, voltage 400-500 kV, and rise time similar to 100 ns. (Chernenko , Proc. of the 11th International Conference of Power Particle Beams, Prague, 1966, p. 154). It is designed as van eight-module machine transmitting electromagnetic power to the low-inductive load through the vacuum line with self-magnetic isolation. Diagnostic techniques and methods on S-300 used are described in this article. Ten-channel polychromator is used for the soft x-ray and vacuum ultraviolet bands (50-500 eV) measurements with spectral resolution of 5%-20% and time resolution less than 2.5 ns. Radiated power measurements in the region of 0.1-10 keV are performed by vacuum x-ray diodes and semiconductor detectors equipped with different filters. Curved crystal x-ray spectrography is intended for plasma density, electron, and ion temperature evaluation. Visible and x-ray radiation image converter tubes and a streak camera reproduce plasma dynamics. Laser shadow and schlieren probing are used to investigate rare periphery plasma motion. Time-of-flight and activation technique is designed for total neutron yield determination. (C) 2001 American Institute of Physics.