Quantitative structure-retention relationships (QSRR) of biogenic amine neurotransmitters and their metabolites on RP-18 plates in thin-layer chromatography

被引:9
作者
Baranowska, I [1 ]
Zydron, M [1 ]
机构
[1] Silesian Tech Univ, Dept Analyt & Gen Chem, PL-44100 Gliwice, Poland
关键词
TLC; QSRR; cluster analysis; biogenic amine neurotransmitters; PHASE LIQUID-CHROMATOGRAPHY; CAPILLARY-ELECTROPHORESIS; URINE; CATECHOLAMINES; ALKALOIDS;
D O I
10.1556/JPC.16.2003.2.3
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The possibility of using molecular descriptors to predict both the retention behavior and the mechanism of retention of biogenic amine neurotransmitters and some of their metabolites in TLC has been examined. QSRR analysis was achieved by simultaneous solution of a set of linear equations. Basic correlations were found between retention and molecular descriptors calculated by means of semi-empirical methods of quantum chemistry. The functions obtained provided insight into the mechanism of chromatographic retention on a molecular level. Experimentally obtained retention data for biogenic amine neurotransmitters and their derivatives also served as a basis for cluster analysis of these TLC systems.
引用
收藏
页码:102 / 106
页数:5
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