Association of serum estrogen level and ischemic neuroprotection in female rats

被引：65

作者：

Liao, SL ^{[1
]}

Chen, WY ^{[1
]}

Kuo, JS ^{[1
]}

Chen, CJ ^{[1
]}

机构：

[1] Taichung Vet Gen Hosp, Dept Educ & Res, Taichung 40705, Taiwan

来源：

NEUROSCIENCE LETTERS | 2001年 / 297卷 / 03期

关键词：

antioxidant enzyme; estrogen; middle cerebral artery; neuroprotection; neutrophil accumulation; post-menopause;

D O I：

10.1016/S0304-3940(00)01704-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Estrogen-related ischemic neuroprotection has been documented in male and ovariectomized female rats. The precise molecular mechanism underlying estrogen's neuroprotective effect remains obscure. In the present study, we examined whether endogenous estrogen levels affect post-ischemic outcomes in normal cycling female rats. Occlusion of both the common carotid arteries and the right middle cerebral artery (1.5 h) followed by reperfusion (24 h) caused cortical infarction, increased neutrophil accumulation, and elevated antioxidant enzyme and lactate dehydrogenase activities. These post-ischemic changes varied in the female rats and were inversely correlated with circulating estrogen levels. More severe post-ischemic changes and injury accompanied the decline in circulating estrogen levels in normal cycling female rats, indicating that estrogen is probably the major hormonal player in female resistance to ischemia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：159 / 162

页数：4

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