Paradoxical reactions in HIV and pulmonary TB

被引：78

作者：

Chien, JW

Johnson, JL

机构：

[1] Univ Hosp Cleveland, Div Infect Dis, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Dept Med, Div Infect Dis, Cleveland, OH 44106 USA

来源：

CHEST | 1998年 / 114卷 / 03期

关键词：

antiretroviral therapy; HIV; immune reconstitution; lymphadenopathy; Mycobacterium tuberculosis; paradoxical reaction;

D O I：

10.1378/chest.114.3.933

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

We present a case of paradoxical clinical deterioration during antituberculosis therapy in an HIV-infected adult with pulmonary TB. The clinical course was characterized hy marked cervical and mediastinal adenopathy accompanied by fever and weight loss during simultaneous treatment of TB and HIV disease. After extensive investigation for causes of therapeutic failure, the paradoxical reaction was attributed to partial immune reconstitution related to highly effective antiretroviral therapy. Due to the high prevalence of TB in HIV-infected patients, it is important to recognize this phenomenon and understand that it is usually self-limited.

引用

页码：933 / 936

页数：4

共 12 条

[1] SUDDEN ENLARGEMENT OF A DEEP CERVICAL LYMPH-NODE DURING AND AFTER TREATMENT FOR PULMONARY TUBERCULOSIS [J].