Y-box binding protein expression in thyroid neoplasms: Its linkage with anaplastic transformation

被引：23

作者：

Ito, Y

Yoshida, H

Shibahara, K

Uruno, T

Nakano, K

Takamura, Y

Miya, A

Kobayashi, K

Yokozawa, T

Matsuzuka, F

Uchimi, T

Kuwano, M

Miyoshi, E

Matsuura, N

Kuma, K

Miyauchi, A

机构：

[1] Kuma Hosp, Dept Surg, Chuo Ku, Kobe, Hyogo 6500011, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Med Biochem, Fukuoka 812, Japan

[3] Osaka Univ, Fac Med, Sch Allied Hlth Sci, Dept Pathol, Osaka, Japan

来源：

PATHOLOGY INTERNATIONAL | 2003年 / 53卷 / 07期

关键词：

immunohistochemistry; thyroid carcinoma; YB-1;

D O I：

10.1046/j.1440-1827.2003.01494.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Recent studies have demonstrated that Y-box binding protein (YB-1) regulates the transcription of genes linked to carcinoma progression. In this study, we investigated the expression of this protein in thyroid, neoplasms to elucidate its significance. The expression of YB-1 was immunohistochemically investigated using the monoclonal antibody for various thyroid neoplasms. Normal follicles did not overexpress YB-1, and only moderate overexpression of YB-1 was observed in some follicular tumors and papillary carcinoma, especially those of a larger size. In contrast, 92.9% of anaplastic carcinoma strongly overexpressed YB-1. YB-1 immunoreactivity was seen in both cytoplasms and cell nuclei, but the former was more predominant. These findings suggest that YB-1 plays a role in regulating the transcription as well as translation of genes contributing to the anaplastic transformation of thyroid carcinoma.

引用

页码：429 / 433

页数：5

共 27 条

[1]

ALDINGER KA, 1978, CANCER-AM CANCER SOC, V41, P2267, DOI 10.1002/1097-0142(197806)41:6<2267::AID-CNCR2820410627>3.0.CO

[2]

2-7

[3] Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression [J].