Rheumatoid arthritis association at 6q23

被引:314
作者
Thomson, Wendy
Barton, Anne
Ke, Xiayi
Eyre, Steve
Hinks, Anne
Bowes, John
Donn, Rachelle
Symmons, Deborah
Hider, Samantha
Bruce, Ian N.
Wilson, Anthony G.
Marinou, Ioanna
Morgan, Ann
Emery, Paul
Carter, Angela
Steer, Sophia
Hocking, Lynne
Reid, David M.
Wordsworth, Paul
Harrison, Pille
Strachan, David
Worthington, Jane [1 ]
机构
[1] Univ Manchester, Arthritis Res Campaign Epidemiol Unit, Manchester M13 9PT, Lancs, England
[2] Univ Sheffield, Sch Med & Biomed Sci, Sheffield S10 2JF, S Yorkshire, England
[3] Chapel Allerton Hosp, Acad Unit Musculoskeletal Dis, Leeds LS7 4SA, W Yorkshire, England
[4] Univ Leeds, Inst Genet, Acad Unit Mol Vasc Med, Hlth & Therapeut Labs, Leeds LS2 9JT, W Yorkshire, England
[5] Kings Coll Hosp London, Natl Hlth Serv Fdn Trust, London SE5 9RS, England
[6] Univ Aberdeen, Dept Med & Therapeut, Bone Res Grp, Aberdeen AB25 2ZD, Scotland
[7] Univ Oxford, Botnar Res Ctr, Inst Musculoskeletal Sci, Oxford OX3 7LD, England
[8] St Georges Univ London, Div Community Hlth Sci, London SW17 0RE, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1038/ng.2007.32
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5)-5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated ( trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 ( TNFAIP3).
引用
收藏
页码:1431 / 1433
页数:3
相关论文
共 13 条
  • [1] The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    Boone, DL
    Turer, EE
    Lee, EG
    Ahmad, RC
    Wheeler, MT
    Tsui, C
    Hurley, P
    Chien, M
    Chai, S
    Hitotsumatsu, O
    McNally, E
    Pickart, C
    Ma, A
    [J]. NATURE IMMUNOLOGY, 2004, 5 (10) : 1052 - 1060
  • [2] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    Burton, Paul R.
    Clayton, David G.
    Cardon, Lon R.
    Craddock, Nick
    Deloukas, Panos
    Duncanson, Audrey
    Kwiatkowski, Dominic P.
    McCarthy, Mark I.
    Ouwehand, Willem H.
    Samani, Nilesh J.
    Todd, John A.
    Donnelly, Peter
    Barrett, Jeffrey C.
    Davison, Dan
    Easton, Doug
    Evans, David
    Leung, Hin-Tak
    Marchini, Jonathan L.
    Morris, Andrew P.
    Spencer, Chris C. A.
    Tobin, Martin D.
    Attwood, Antony P.
    Boorman, James P.
    Cant, Barbara
    Everson, Ursula
    Hussey, Judith M.
    Jolley, Jennifer D.
    Knight, Alexandra S.
    Koch, Kerstin
    Meech, Elizabeth
    Nutland, Sarah
    Prowse, Christopher V.
    Stevens, Helen E.
    Taylor, Niall C.
    Walters, Graham R.
    Walker, Neil M.
    Watkins, Nicholas A.
    Winzer, Thilo
    Jones, Richard W.
    McArdle, Wendy L.
    Ring, Susan M.
    Strachan, David P.
    Pembrey, Marcus
    Breen, Gerome
    St Clair, David
    Caesar, Sian
    Gordon-Smith, Katherine
    Jones, Lisa
    Fraser, Christine
    Green, Elain K.
    [J]. NATURE, 2007, 447 (7145) : 661 - 678
  • [3] The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord
    Filippi, A
    Tiso, N
    Deflorian, G
    Zecchin, E
    Bortolussi, M
    Argenton, F
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (12) : 4377 - 4382
  • [4] Risk alleles for multiple sclerosis identified by a genomewide study
    Hafler, David A.
    Compston, Alastair
    Sawcer, Stephen
    Lander, Eric S.
    Daly, Mark J.
    De Jager, Philip L.
    de Bakker, Paul I. W.
    Gabriel, Stacey B.
    Mirel, Daniel B.
    Ivinson, Adrian J.
    Pericak-Vance, Margaret A.
    Gregory, Simon G.
    Rioux, John D.
    McCauley, Jacob L.
    Haines, Jonathan L.
    Barcellos, Lisa F.
    Cree, Bruce
    Oksenberg, Jorge R.
    Hauser, Stephen L.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (09) : 851 - 862
  • [5] Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients
    Harrison, P.
    Pointon, J. J.
    Farrar, C.
    Brown, M. A.
    Wordsworth, B. P.
    [J]. RHEUMATOLOGY, 2006, 45 (08) : 1009 - 1011
  • [6] Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population -: Further support that PTPN22 is an autoimmunity gene
    Hinks, A
    Barton, A
    John, S
    Bruce, I
    Hawkins, C
    Griffiths, CEM
    Donn, R
    Thomson, W
    Silman, A
    Worthington, J
    [J]. ARTHRITIS AND RHEUMATISM, 2005, 52 (06): : 1694 - 1699
  • [7] Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins
    Huizinga, TWJ
    Amos, CI
    van der Helm-van Mil, AHM
    Chen, W
    van Gaalen, FA
    Jawaheer, D
    Schreuder, GMT
    Wener, M
    Breedveld, FC
    Ahmad, N
    Lum, RF
    de Vries, RRP
    Gregersen, PK
    Toes, REM
    Criswell, LA
    [J]. ARTHRITIS AND RHEUMATISM, 2005, 52 (11): : 3433 - 3438
  • [8] A new model for an etiology of rheumatoid arthritis
    Klareskog, L
    Stolt, P
    Lundberg, K
    Källberg, H
    Bengtsson, C
    Grunewald, J
    Rönnelid, J
    Harris, HE
    Ulfgren, AK
    Rantapää-Dahlqvist, S
    Eklund, A
    Padyukov, L
    Alfredsson, L
    [J]. ARTHRITIS AND RHEUMATISM, 2006, 54 (01): : 38 - 46
  • [9] Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice
    Lee, EG
    Boone, DL
    Chai, S
    Libby, SL
    Chien, M
    Lodolce, JP
    Ma, A
    [J]. SCIENCE, 2000, 289 (5488) : 2350 - 2354
  • [10] Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
    Lowe, Christopher E.
    Cooper, Jason D.
    Brusko, Todd
    Walker, Neil M.
    Smyth, Deborah J.
    Bailey, Rebecca
    Bourget, Kirsi
    Plagnol, Vincent
    Field, Sarah
    Atkinson, Mark
    Clayton, David G.
    Wicker, Linda S.
    Todd, John A.
    [J]. NATURE GENETICS, 2007, 39 (09) : 1074 - 1082