Estimators for pairwise relatedness and individual inbreeding coefficients

被引:608
作者
Ritland, K
机构
关键词
D O I
10.1017/S0016672300033620
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Method-of-moments estimators (MMEs) for the two-gene coefficients of relationship and inbreeding, and for the four-gene Cotterman coefficients, are described. These estimators, which use co-dominant genetic markers, are most appropriate for estimating pairwise relatedness or individual inbreeding coefficients, as opposed to their mean values in a group. This is because, compared to the maximum likelihood estimate (MLE), they show reduced small-sample bias and lack distributional assumptions. The 'efficient' MME is an optimally weighted average of estimates given by each allele at each locus. Generally, weights must be computed numerically, but if true coefficients are assumed zero, simplified estimators are obtained whose relative efficiencies are quite high. Population gene frequency is assumed to be assayed in a larger, 'reference population' sample, and the biases introduced by small reference samples and/or genetic drift of the reference population are discussed. Individual-level estimates of relatedness or inbreeding, while displaying high variance, are useful in several applications as a covariate in population studies.
引用
收藏
页码:175 / 185
页数:11
相关论文
共 33 条
[1]  
[Anonymous], 1990, GENETIC DATA ANAL
[2]  
BARBUJANI G, 1987, GENETICS, V117, P777
[3]  
BROWN AHD, 1985, LECTURE NOTES BIOMAT, V60, P32
[4]  
CHAKRABORTY R, 1988, GENETICS, V118, P527
[5]  
Cotterman C. W, 1940, CALCULUS STAT GENETI
[6]   The variant call format and VCFtools [J].
Danecek, Petr ;
Auton, Adam ;
Abecasis, Goncalo ;
Albers, Cornelis A. ;
Banks, Eric ;
DePristo, Mark A. ;
Handsaker, Robert E. ;
Lunter, Gerton ;
Marth, Gabor T. ;
Sherry, Stephen T. ;
McVean, Gilean ;
Durbin, Richard .
BIOINFORMATICS, 2011, 27 (15) :2156-2158
[7]  
CRUZAN M, 1996, IN PRESS GENETIC MAR
[8]  
CURIECOHEN M, 1982, GENETICS, V100, P339
[9]   A COMPARISON OF TESTS FOR HARDY-WEINBERG EQUILIBRIUM [J].
EMIGH, TH .
BIOMETRICS, 1980, 36 (04) :627-642
[10]  
Epperson BK, 1989, PLANT POPULATION GEN, P229