Cytokine-mediated inflammation in acute lung injury

被引：893

作者：

Goodman, RB

Pugin, J

Lee, JS

Matthay, MA

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, Dept Med, San Francisco, CA 94143 USA

[2] Univ Washington, Sch Med,Div Pulm & Crit Care, VA Puget Sound Med Ctr,Dept Vet Affairs, VA Puget Sound Hlth Care Syst,VA Pulm Res Labs, Seattle, WA 98108 USA

[3] Univ Washington, Sch Med,Div Pulm & Crit Care, VA Puget Sound Med Ctr,Dept Med, VA Puget Sound Hlth Care Syst,VA Pulm Res Labs, Seattle, WA 98108 USA

[4] Univ Hosp Geneva, Dept Med, Div Med Intens Care, CH-1211 Geneva 14, Switzerland

[5] Univ Calif San Francisco, Cardiovasc Res Inst, Dept Anesthesia, San Francisco, CA 94143 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2003年 / 14卷 / 06期

关键词：

chemokine; interleukins; acute respiratory distress syndrome (ARDS); pulmonary edema;

D O I：

10.1016/S1359-6101(03)00059-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Clinical acute lung injury (ALI) is a major cause of acute respiratory failure in critically ill patients. There is considerable experimental and clinical evidence that pro- and anti-inflammatory cytokines play a major role in the pathogenesis of inflammatory-induced lung injury from sepsis, pneumonia, aspiration, and shock. A recent multi-center clinical trial found that a lung-protective ventilatory strategy reduces mortality by 22% in patients with ALI. Interestingly, this protective ventilatory strategy was associated with a marked reduction in the number of neutrophils and the concentration of pro- inflammatory cytokines released into the airspaces of the injured lung. Further research is needed to establish the contribution of cytokines to both the pathogenesis and resolution of ALI. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：523 / 535

页数：13

共 170 条

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p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock - A randomized controlled multicenter trial [J].