Studies of selective Boc removal in the presence of silyl ethers

被引：32

作者：

Cavelier, F

Enjalbal, C

机构：

[1] Lab. d'Aminoacides, Peptides et P., Associé au CNRS, Université Montpellier II

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 29期

关键词：

D O I：

10.1016/0040-4039(96)01070-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The selective removal of N-Boc protection can be obtained in the presence of either TBDMS or TBDPS ethers. On the basis of promising results from the literature, we first tried sonication, that failed, whereas the exclusive cleavage of the Boc group was successfully achieved by a saturated solution of HCl in ethylacetate. Copyright (C) 1996 Published by Elsevier Science Ltd

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页码：5131 / 5134

页数：4

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