Immunosenescence and infectious diseases

被引：200

作者：

Ginaldi, L ^{[1
]}

Loreto, MF ^{[1
]}

Corsi, MP ^{[1
]}

Modesti, M ^{[1
]}

De Martinis, M ^{[1
]}

机构：

[1] Univ Aquila, Dept Internal Med & Publ Hlth, I-67100 Laquila, Italy

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 10期

关键词：

aging; immune system; immunosenescence; infectious diseases;

D O I：

10.1016/S1286-4579(01)01443-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infectious diseases are major causes, with malignancies, of morbidity and mortality in the elderly. Increased susceptibility to infections may result from underlying dysfunction of an aged immune system; moreover, inappropriate immunologic functions associated with aging can determine an insufficient response to vaccines. Impairments of cellular, humoral and innate immunity in the elderly, contributing to increased incidence of infectious diseases, are discussed in this review. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：851 / 857

页数：7

共 35 条

[1] Clinical relevance of age-related immune dysfunction [J].

Castle, SC .

CLINICAL INFECTIOUS DISEASES, 2000, 31 (02) :578-585

[2] EFFECT OF VITAMIN AND TRACE-ELEMENT SUPPLEMENTATION ON IMMUNE-RESPONSES AND INFECTION IN ELDERLY SUBJECTS [J].

CHANDRA, RK .

LANCET, 1992, 340 (8828) :1124-1127

[3]

Cossarizza A, 1997, CYTOMETRY, V27, P297, DOI 10.1002/(SICI)1097-0320(19970401)27:4<297::AID-CYTO1>3.0.CO

[4]

2-A

[5] Adhesion molecules on peripheral blood lymphocyte subpopulations in the elderly [J].

De Martinis, M ;

Modesti, M ;

Loreto, MF ;

Quaglino, D ;

Ginaldi, L .

LIFE SCIENCES, 2000, 68 (02) :139-151

[6]

Dey AB, 1997, INDIAN J MED RES, V106, P273

[7]

ENGWERDA CR, 1994, J IMMUNOL, V152, P3740

[8] Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging [J].

Fagnoni, FF ;

Vescovini, R ;

Passeri, G ;

Bologna, G ;

Pedrazzoni, M ;

Lavagetto, G ;

Casti, A ;

Franceschi, C ;

Passeri, M ;

Sansoni, P .

BLOOD, 2000, 95 (09) :2860-2868

[9] IMMUNE PARAMETERS IN A LONGITUDINAL-STUDY OF A VERY OLD POPULATION OF SWEDISH PEOPLE - A COMPARISON BETWEEN SURVIVORS AND NONSURVIVORS [J].

FERGUSON, FG ;

WIKBY, A ;

MAXSON, P ;

OLSSON, J ;

JOHANSSON, B .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1995, 50 (06) :B378-B382

[10]

Franceschi C, 2000, ANN NY ACAD SCI, V908, P244

← 1 2 3 4 →