Engineering the pre-metastatic niche

被引：102

作者：

Aguado, Brian A. ^{[1
,2
]}

Bushnell, Grace G. ^{[3
]}

Rao, Shreyas S. ^{[4
]}

Jeruss, Jacqueline S. ^{[5
,6
,7
]}

Shea, Lonnie D. ^{[3
]}

机构：

[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[2] Northwestern Univ, Simpson Querrey Inst BioNanotechnol, Chicago, IL 60611 USA

[3] Univ Michigan, Dept Biomed Engn, 1119 Carl A Gerstacker Bldg,2200 Bonisteel Blvd, Ann Arbor, MI 48109 USA

[4] Univ Alabama, Dept Chem & Biol Engn, Tuscaloosa, AL 35487 USA

[5] Univ Michigan, Div Surg Oncol, Dept Surg, 3303 Canc Ctr,1500 East Med Ctr Dr, Ann Arbor, MI 48105 USA

[6] Univ Michigan, Div Surg Oncol, Dept Pathol, 3303 Canc Ctr,1500 East Med Ctr Dr, Ann Arbor, MI 48105 USA

[7] Univ Michigan, Div Surg Oncol, Dept Biomed Engn, 3303 Canc Ctr,1500 East Med Ctr Dr, Ann Arbor, MI 48105 USA

来源：

NATURE BIOMEDICAL ENGINEERING | 2017年 / 1卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

BREAST-CANCER METASTASIS; CIRCULATING TUMOR-CELLS; IN-VITRO MODEL; EXTRACELLULAR-MATRIX; FUCOSYLATED HAPTOGLOBIN; IMPLANTABLE SCAFFOLDS; BIOLOGICAL-PROPERTIES; SUPPRESSOR-CELLS; IMMUNE-RESPONSES; LUNG METASTASIS;

D O I：

10.1038/s41551-017-0077

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The pre-metastatic niche -the accumulation of aberrant immune cells and extracellular-matrix proteins in target organs primes the initially healthy organ microenvironment and renders it amenable for subsequent colonization by metastatic cancer cells. By attracting metastatic cells, mimics of the pre-metastatic niche offer both diagnostic and therapeutic potential. However, deconstructing the complexity of the niche by identifying the interactions between cell populations as well as the mediatory roles of the immune system, soluble factors, extracellular-matrix proteins and stromal cells has proved challenging. Experimental models are needed to recapitulate niche-population biology in situ and to mediate in vivo tumour-cell homing, colonization and proliferation. In this Review, we outline the biology of the pre-metastatic niche and discuss advances in the engineering of niche-mimicking biomaterials that regulate the behaviour of tumour cells at an implant site. Such 'oncomaterials' offer strategies for the early detection of metastatic events, the inhibition of the formation of the pre-metastatic niche and the attenuation of metastatic progression.

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