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Aurora kinases link chromosome segregation and cell division to cancer susceptibility

被引：281
作者：
Meraldi, P
Honda, R
Nigg, EA
机构：
[1] Max Planck Inst Biochem, Dept Cell Biol, D-82152 Martinsried, Germany
[2] MIT, Dept Biol, Cambridge, MA 02139 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 01期
关键词：
D O I：
10.1016/j.gde.2003.11.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Aurora kinases play critical roles in chromosome segregation and cell division. They are implicated in the centrosome cycle, spindle assembly, chromosome condensation, microtubule-kinetochore attachment, the spindle checkpoint and cytokinesis. Aurora kinases are regulated through phosphorylation, the binding of specific partners and ubiquitin-dependent proteolysis. Several Aurora substrates have been identified and their roles are being elucidated. The deregulation of Aurora kinases impairs spindle assembly, checkpoint function and cell division, causing missegregation of individual chromosomes or polyploidlization accompanied by centrosome amplification. Aurora kinases are frequently overexpressed in cancers and the identification of Aurora A as a cancer-susceptibility gene provides a strong link between mitotic errors and carcinogenesis.
引用
收藏
页码：29 / 36
页数：8
相关论文
共 62 条
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