Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette

被引：33

作者：

Chapman, Kevin E. ^{[1
]}

Raol, Yogendra H. ^{[1
]}

Brooks-Kayal, Amy ^{[1
]}

机构：

[1] Univ Colorado, Childrens Hosp Colorado, Sect Pediat Neurol, Dept Pediat,Sch Med, Aurora, CO 80045 USA

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2012年 / 35卷 / 12期

关键词：

epilepsy; rodent models; translational research; treatment; HYPOXIC-ISCHEMIC ENCEPHALOPATHY; RECEPTOR SUBUNIT EXPRESSION; VITAMIN-D-RECEPTOR; AMPLITUDE-INTEGRATED ELECTROENCEPHALOGRAPHY; INDUCED STATUS EPILEPTICUS; CEREBRAL WHITE-MATTER; EARLY-LIFE SEIZURES; DEVELOPING BRAIN; MOUSE MODEL; POSTNATAL-DEVELOPMENT;

D O I：

10.1111/j.1460-9568.2012.08140.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neonatal seizures have unique properties that have proved challenging for both clinicians and basic science researchers. Clinical therapies aimed at neonatal seizures have proven only partially effective and new therapies are slow to develop. This article will discuss neonatal seizures within the framework of the barriers that exist to the development of new therapies, and the challenges inherent in bringing new therapies from the bench to the bedside. With the European Union and USA creating national collaborative project infrastructure, improved collaborative resources should advance clinical research on urgently needed new therapies for this disorder.

引用

页码：1857 / 1865

页数：9

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