Increased plasma levels of TNF-α but not of IL1-β in MPTP-treated monkeys one year after the MPTP administration

被引：47

作者：

Barcia, C ^{[1
]}

de Pablos, V ^{[1
]}

Bautista-Hernández, V ^{[1
]}

Sánchez-Bahillo, A ^{[1
]}

Bernal, I ^{[1
]}

Fernández-Villalba, E ^{[1
]}

Martín, J ^{[1
]}

Bañón, R ^{[1
]}

Fernández-Barreiro, A ^{[1
]}

Herrero, MT ^{[1
]}

机构：

[1] Univ Murcia, Sch Med, Dept Human Anat & Psychobiol, E-30100 Murcia, Spain

来源：

PARKINSONISM & RELATED DISORDERS | 2005年 / 11卷 / 07期

关键词：

Parkinson's disease; inflammation; cytokines;

D O I：

10.1016/j.parkreldis.2005.05.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The cause of Parkinson's disease remains unknown although some evidence suggests that an inflammatory reaction, mediated by cytokines such as TNF-alpha and IL-1 beta, is related with dopaminergic degeneration in the brain. In the present work we measured the plasma levels of TNF-alpha and IL-1 beta in parkinsonian monkeys one year after MPTP administration. TNF-alpha levels were seen to have increased in parkinsonian monkeys reflecting the clinical symptoms observed, while IL-1 beta levels remained unchanged. These results suggest that TNF-alpha plays a role in sustaining of dopaminergic degeneration in chronic parkinsonism. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：435 / 439

页数：5

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