Light-Triggered Theranostics Based on Photosensitizer-Conjugated Carbon Dots for Simultaneous Enhanced-Fluorescence Imaging and Photodynamic Therapy

被引：623

作者：

Huang, Peng ^{[1
,2
]}

Lin, Jing ^{[1
]}

Wang, Xiansong ^{[1
]}

Wang, Zhe ^{[2
]}

Zhang, Chunlei ^{[1
]}

He, Meng ^{[1
]}

Wang, Kan ^{[1
]}

Chen, Feng ^{[1
]}

Li, Zhiming ^{[1
]}

Shen, Guangxia ^{[1
]}

Cui, Daxiang ^{[1
]}

Chen, Xiaoyuan ^{[2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Inst Micronano Sci & Technol, Shanghai 200240, Peoples R China

[2] NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA

[3] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361005, Peoples R China

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 37期

关键词：

theranostics; carbon dots; chlorin e6; fluorescence imaging; photodynamic therapy; MODIFIED GOLD NANORODS; QUANTUM DOTS; MULTIFUNCTIONAL NANOPARTICLES; PHOTOTHERMAL THERAPY; DELIVERY; GENERATION; PORPHYRIN; RADIATION; RELEASE; PEPTIDE;

D O I：

10.1002/adma.201200650

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel theranostics based on photosensitizer-conjugated carbon dots is reported. The prepared C-dots-Ce6 has good stability and high water dispersibility and solubility, non-cytotoxicity, good biocompatibility, enhanced photosensitizer fluorescence detection and remarkable photodynamic efficacy upon irradiation. The C-dots-Ce6 conjugate is a good candidate with excellent imaging and tumor-homing ability for NIR fluorescence imaging monitored PDT treatment. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5104 / 5110

页数：7

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