Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling

被引：201

作者：

Aguiar, Aderbal S., Jr. ^{[1
]}

Castro, Adalberto A. ^{[2
]}

Moreira, Eduardo L. ^{[1
]}

Glaser, Viviane ^{[2
]}

Santos, Adair R. S. ^{[3
]}

Tasca, Carla I. ^{[2
]}

Latini, Alexandra ^{[2
]}

Prediger, Rui D. S. ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Dept Farmacol, BR-88049900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Bioquim, BR-88049900 Florianopolis, SC, Brazil

[3] Univ Fed Santa Catarina, Dept Ciencias Fisiol, BR-88049900 Florianopolis, SC, Brazil

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2011年 / 132卷 / 11-12期

关键词：

Aging; Physical exercise; Learning and memory; Hippocampus; Synaptic plasticity; BDNF; Glutamate; ELEMENT-BINDING PROTEIN; LONG-TERM POTENTIATION; LACTATE STEADY-STATE; OLDER-ADULTS; NEUROTROPHIC FACTOR; DENTATE GYRUS; CARDIOVASCULAR FITNESS; COGNITIVE DECLINE; SKELETAL-MUSCLE; NERVOUS-SYSTEM;

D O I：

10.1016/j.mad.2011.09.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the present study, we investigated whether mild-intensity physical exercise represents a successful strategy to enhance spatial learning and memory and hippocampal plasticity in aging rats, as previously described for long-term exposure to running wheel or treadmill exercise. Aging Wistar rats were submitted to short bouts (4-6 min) of exercise treadmill during five consecutive weeks. This mild-intensity exercise program increased muscle oxygen consumption by soleus and heart in aging rats and reversed age-related long-term spatial learning and memory impairments evaluated in the water maze and step-down inhibitory avoidance tasks. Remarkably, the observed cognitive-enhancing properties of short bouts of exercise were accompanied by the activation of serine/threonine protein kinase (Ala) and cAMP response element binding (CREB) pro-survival signaling that culminates in the marked increase on the brain-derived neurotrophic factor (BDNF) mRNA expression and BDNF protein levels on the hippocampus of aging rats. Altogether, these results indicate that short bouts of exercise represent a viable behavioral strategy to improve cognition and synaptic plasticity in aging rats which should be taken into account in further studies addressing the effects of physical exercise in aging subjects. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：560 / 567

页数：8

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