Determination of activity for nociceptin in the mouse vas deferens

被引：62

作者：

BerzeteiGurske, IP

Schwartz, RW

Toll, L

机构：

[1] Department of Neuroscience, SRI International, Menlo Park, CA

[2] SRI International, Department of Neuroscience, Bldg. LA, Menlo Park, CA 94025

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 302卷 / 1-3期

关键词：

nociceptin; ORL(1); vas deferens; mouse;

D O I：

10.1016/0014-2999(96)00238-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The recently discovered neuropeptide nociceptin was found to inhibit electrically induced contractions of the mouse vas deferens. Nociceptin and its 14-Tyr analog were each partial agonists, but with high affinity (ED(50) of 20 nM). This activity was not opioid in nature, as it was not inhibited by either selective or non-selective opiate antagonists.

引用

收藏

页码：R1 / R2

页数：2

相关论文

共 7 条

[1] EFFECT OF MORPHINE ON ADRENERGIC TRANSMISSION IN MOUSE VAS-DEFERENS ASSESSMENT OF AGONIST AND ANTAGONIST POTENCIES OF NARCOTIC ANALGESICS [J].

HUGHES, J ;

KOSTERLITZ, HW ;

LESLIE, FM .

BRITISH JOURNAL OF PHARMACOLOGY, 1975, 53 (03) :371-381

[2] ENDOGENOUS OPIOID PEPTIDES - MULTIPLE AGONISTS AND RECEPTORS [J].

LORD, JAH ;

WATERFIELD, AA ;

HUGHES, J ;

KOSTERLITZ, HW .

NATURE, 1977, 267 (5611) :495-499

[3] ISOLATION AND STRUCTURE OF THE ENDOGENOUS AGONIST OF OPIOID RECEPTOR-LIKE ORL(1) RECEPTOR [J].

MEUNIER, JC ;

MOLLEREAU, C ;

TOLL, L ;

SUAUDEAU, C ;

MOISAND, C ;

ALVINERIE, P ;

BUTOUR, JL ;

GUILLEMOT, JC ;

FERRARA, P ;

MONSARRAT, B ;

MAZARGUIL, H ;

VASSART, G ;

PARMENTIER, M ;

COSTENTIN, J .

NATURE, 1995, 377 (6549) :532-535

[4] ORL1, A NOVEL MEMBER OF THE OPIOID RECEPTOR FAMILY - CLONING, FUNCTIONAL EXPRESSION AND LOCALIZATION [J].

MOLLEREAU, C ;

PARMENTIER, M ;

MAILLEUX, P ;

BUTOUR, JL ;

MOISAND, C ;

CHALON, P ;

CAPUT, D ;

VASSART, G ;

MEUNIER, JC .

FEBS LETTERS, 1994, 341 (01) :33-38

[5] ORPHANIN-FQ - A NEUROPEPTIDE THAT ACTIVATES AN OPIOID-LIKE G-PROTEIN-COUPLED RECEPTOR [J].

REINSCHEID, RK ;

NOTHACKER, HP ;

BOURSON, A ;

ARDATI, A ;

HENNINGSEN, RA ;

BUNZOW, JR ;

GRANDY, DK ;

LANGEN, H ;

MONSMA, FJ ;

CIVELLI, O .

SCIENCE, 1995, 270 (5237) :792-794

[6] DIFFERENTIAL BEHAVIOR OF LPH-(61-91)-PEPTIDE IN DIFFERENT MODEL SYSTEMS - COMPARISON OF OPIOID ACTIVITIES OF LPH-(61-91)-PEPTIDE AND ITS FRAGMENTS [J].

RONAI, AZ ;

GRAF, L ;

SZEKELY, JI ;

DUNAIKOVACS, Z ;

BAJUSZ, S .

FEBS LETTERS, 1977, 74 (02) :182-184

[7] SELECTIVE RECEPTORS FOR BETA-ENDORPHIN ON THE RAT VAS-DEFERENS [J].

SCHULZ, R ;

FAASE, E ;

WUSTER, M ;

HERZ, A .

LIFE SCIENCES, 1979, 24 (09) :843-849