Increased neuropeptide Y pressor activity in Goldblatt hypertensive rats: in vivo studies with BIBP 3226

被引：12

作者：

Mezzano, V ^{[1
]}

Donoso, V ^{[1
]}

Capurro, D ^{[1
]}

Huidobro-Toro, JP ^{[1
]}

机构：

[1] Pontificia Univ Catolica Chile, Fac Biol Sci, Dept Fisiol, Unidad Regulac Neurohumoral, POB 114-D, Santiago, Chile

来源：

PEPTIDES | 1998年 / 19卷 / 07期

关键词：

neuropeptide Y; neuropeptide Y Y-1 receptors; BIBP 3226 competitive antagonism; arterial blood pressure; Goldblatt hypertension;

D O I：

10.1016/S0196-9781(98)00031-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nanomoles of neuropeptide Y (NPY) and noradrenaline (NA), administered IV to pentobarbital-anesthetized rats, caused nearly equipotent dose-dependent presser responses in normotensive rats. However, in renovascular Goldblatt hypertensive rats, the dose-response curves for both NPY and NA were significantly displaced to the left, approximately threefold. Intravenous administration of BIBP 3226 (30-180 mu g/kg) did not consistently lower blood pressure, per se, but did evoke competitive antagonism of the NPY presser response in both rat populations. The magnitude of the NPY antagonism evoked by BIBP 3226 was comparable in normotensive and hypertensive rats. The absence of NA antagonism demonstrates the selectivity of the BIBP 3226 blockade. (C) 1998 Elsevier Science Inc.

引用

页码：1227 / 1232

页数：6

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