High rate of mobilization for blaCTX-Ms

被引：42

作者：

Barlow, Miriam ^{[1
]}

Reik, Rebecca A. ^{[2
]}

Jacobs, Stephen D. ^{[1
]}

Medina, Monica ^{[1
]}

Meyer, Matthew P. ^{[1
]}

McGowan, John E., Jr. ^{[2
]}

Tenover, Fred C. ^{[3
]}

机构：

[1] Univ Calif Merced, Merced, CA 95344 USA

[2] Emory Univ, Atlanta, GA 30322 USA

[3] Ctr Dis Control & Prevent, Atlanta, GA USA

来源：

EMERGING INFECTIOUS DISEASES | 2008年 / 14卷 / 03期

关键词：

D O I：

10.3201/eid1403.070405

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We constructed a phylogenetic analysis of class A beta-lactamases and found that the bla (CTX-M)s have been mobilized to plasmids approximate to 10 times more frequently than other class A beta-lactamases. We also found that the bla(CTX-M)s are descended from a common ancestor that was incorporated in ancient times into the chromosome of the ancestor of Kluyvera species through horizontal transfer. Considerable sequence divergence has occurred among the descendents of that ancestral gene sequence since that gene was inserted. That divergence has mainly occurred in the presence of purifying selection, which indicates a slow rate of evolution for bla(CTX-M)s in the pre-antimicrobial drug era.

引用

页码：423 / 428

页数：6

共 40 条

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