Effects of hyperbaric oxygen on energy production and xanthine oxidase levels in striated muscle tissue of healthy rats

被引：19

作者：

Kurt, Buelent ^{[1
]}

Kurt, Yasemin ^{[1
,2
]}

Karslioglu, Ydirim ^{[1
]}

Topal, Turgut ^{[1
,3
]}

Erdamar, Huesamettin ^{[5
]}

Korkmaz, Ahmet ^{[1
,3
]}

Tuerkoezkan, Nurten ^{[5
]}

Yaman, Halil ^{[1
,2
]}

Odabasi, Zeki ^{[1
,4
]}

Guenhan, Oemer ^{[1
]}

机构：

[1] Gulhane Mil Med Acad & Med Sch, Dept Pathol, Ankara, Turkey

[2] Gulhane Mil Med Acad & Med Sch, Dept Biochem, Ankara, Turkey

[3] Gulhane Mil Med Acad & Med Sch, Dept Physiol, Ankara, Turkey

[4] Gulhane Mil Med Acad & Med Sch, Dept Neurol, Ankara, Turkey

[5] Gazi Univ, Dept Biochem, Ankara, Turkey

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2008年 / 15卷 / 04期

关键词：

heteroplasmic mitochondrial disease; hyperbaric oxygen; ATP;

D O I：

10.1016/j.jocn.2007.01.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the effects of hyperbaric oxygen (HBO) treatment on striated muscle tissue in healthy rats. The treatment group of rats (n = 16) was given HBO daily on weekdays for 2 h over a 4-week period while a control group (n = 8) was not treated. Tissue samples were taken from the left and right vastus lateralis before and after the HBO treatment period, respectively, for all rats in both groups. Levels of adenosine monophosphate (AMP), adenosine diphosphate, andenosine triphosphate (ATP) and xanthine oxidase in the muscle tissue were determined. HBO treatment caused a statistically significant increase in ATP (p = 0.001) and decrease in AMP (p = 0.02) in the HBO-treated group, while there were no significant differences in metabolites in the control group. These results suggest that HBO treatment induces an increase in the ATP levels of muscle tissue with normal mitochondria. Thus, HBO might have some beneficial effects in the treatment of heteroplasmic mitochondrial disease, where normal and defective mitochondria coexist. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：445 / 450

页数：6

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