Clinical trials of riluzole in patients with ALS

被引：65

作者：

Miller, RG

Bouchard, JP

Duquette, P

Eisen, A

Gelinas, DF

Harati, Y

Munsat, TL

Powe, L

Rothstein, J

Salzman, P

Sufit, RL

Guillet, P

Bensimon, G

Delumeau, JC

Durrleman, S

Lacomblez, L

Leigh, PN

Meininger, V

Maloteaux, JM

Delwaide, C

Girard, M

Masse, C

Blin, O

Azulay, JP

Billeturc, F

Pouget, J

Bouche, P

Camu, W

Carlander, B

Clanet, M

Angibaud, G

ArneBes, MC

Benazet, M

Couratier, P

Desnuelle, C

Lagueny, A

Ellie, E

Dib, M

Rozier, A

Salachas, F

Viader, F

Delaunay, D

Dengler, R

Guther, G

Troger, M

Ludolph, A

Bachus, R

Gericke, C

Przuntek, H

Langkafel, M

机构：

[1] HOP ENFANTS JESUS, DEPT NEUROL SCI, QUEBEC CITY, PQ, CANADA

[2] NOTRE DAME HOSP, DEPT NEUROL, MONTREAL, PQ, CANADA

[3] VANCOUVER HOSP & HLTH SCI CTR, NEUROMUSCULAR DIS UNIT, VANCOUVER, BC V5Z 1M9, CANADA

[4] BAYLOR COLL MED, DEPT NEUROL, HOUSTON, TX 77030 USA

[5] TUFTS UNIV NEW ENGLAND MED CTR, DEPT NEUROL, BOSTON, MA 02111 USA

[6] RHONE POULENC RORER, ANTONY, FRANCE

[7] RHONE POULENC RORER, COLLEGEVILLE, PA USA

[8] NORTHWESTERN UNIV, SCH MED, DEPT NEUROL, CHICAGO, IL 60611 USA

[9] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROL, BALTIMORE, MD 21205 USA

[10] HOP LA PITIE SALPETRIERE, DEPT PHARMACOL, PARIS, FRANCE

[11] INST PSYCHIAT, DEPT NEUROL, LONDON SE5 8AF, ENGLAND

[12] UNIV LOUVAIN, BRUSSELS, BELGIUM

[13] HOP ENFANTS LA TIMONE, MARSEILLE, FRANCE

[14] HOP G CHAULIAC, MONTPELLIER, FRANCE

[15] HOP PURPAN, TOULOUSE, FRANCE

[16] HOP LOUIS PASTEUR, F-06002 NICE, FRANCE

[17] HOP HAUT LEVEQUE, PESSAC, FRANCE

[18] HOP DUPUYTEN, LIMOGES, FRANCE

[19] CHU COTE NACRE, CAEN, FRANCE

[20] HANNOVER MED SCH, HANNOVER, GERMANY

[21] UNIV BERLIN, NEUROL KLIN, BERLIN, GERMANY

[22] INST SALUD CARLOS III, MADRID, SPAIN

[23] QUEENS MED CTR, NOTTINGHAM NG7 2UH, ENGLAND

[24] CHARING CROSS HOSP, LONDON, ENGLAND

[25] ROYAL PRESTON HOSP, PRESTON, LANCS, ENGLAND

[26] QUEEN ELIZABETH HOSP, BIRMINGHAM B15 2TH, W MIDLANDS, ENGLAND

[27] MANCHESTER ROYAL INFIRM, MANCHESTER M13 9WL, LANCS, ENGLAND

[28] QUEEN VICTORIA INFIRM, NEWCASTLE UPON TYNE, TYNE & WEAR, ENGLAND

[29] ROYAL LONDON HOSP, LONDON E1 1BB, ENGLAND

[30] BAYLOR COLL MED, HOUSTON, TX USA

[31] VAMC, HOUSTON, TX USA

[32] CALIF PACIFIC MED CTR, SAN FRANCISCO, CA USA

来源：

NEUROLOGY | 1996年 / 47卷 / 04期

关键词：

D O I：

10.1212/WNL.47.4_Suppl_2.86S

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two double-blinded, placebo-controlled clinical trials of riluzole have now been carried out in more than 1,100 patients with ALS. The results of both studies show a modest benefit in prolonging survival that is statistically significant. These results led to the availability of this drug by the Food and Drug Administration for use in the United States beginning in early 1996. This is the first drug that has been available for ALS. It begins a new era in both basic and clinical research in an attempt to find a cure for this disease.

引用

页码：S86 / S90

页数：5

共 18 条

[1] LONG-TERM SAFETY OF AZATHIOPRINE THERAPY IN MULTIPLE-SCLEROSIS [J].

AMATO, MP ;

PRACUCCI, G ;

PONZIANI, G ;

SIRACUSA, G ;

FRATIGLIONI, L ;

AMADUCCI, L .

NEUROLOGY, 1993, 43 (04) :831-833

[2] A CONTROLLED TRIAL OF RILUZOLE IN AMYOTROPHIC-LATERAL-SCLEROSIS [J].

BENSIMON, G ;

LACOMBLEZ, L ;

MEININGER, V ;

BOUCHE, P ;

DELWAIDE, C ;

COURATIER, P ;

BLIN, O ;

VIADER, F ;

PEYROSTPAUL, H ;

DAVID, J ;

MALOTEAUX, JM ;

HUGON, J ;

LATERRE, EC ;

RASCOL, A ;

CLANET, M ;

VALLAT, JM ;

DUMAS, A ;

SERRATRICE, G ;

LECHEVALLIER, B ;

PEUCH, AJ ;

NGUYEN, T ;

SHU, C ;

BASTIEN, P ;

PAPILLON, C ;

DURRLEMAN, S ;

LOUVEL, E ;

GUILLET, P ;

LEDOUX, L ;

ORVOENFRIJA, E ;

DIB, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (09) :585-591

[3] GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM [J].

CHOI, DW .

NEURON, 1988, 1 (08) :623-634

[4] PROTECTIVE EFFECT OF RILUZOLE ON EXCITATORY AMINO ACID-MEDIATED NEUROTOXICITY IN MOTONEURON-ENRICHED CULTURES [J].

ESTEVEZ, AG ;

STUTZMANN, JM ;

BARBEITO, L .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 280 (01) :47-53

[5]

Herbert T, 1994, MOL PHARMACOL, V45, P1055

[6] HEPATOTOXIC REACTIONS ASSOCIATED WITH CARBAMAZEPINE THERAPY [J].

HOROWITZ, S ;

PATWARDHAN, R ;

MARCUS, E .

EPILEPSIA, 1988, 29 (02) :149-154

[7] ANTAGONISM BY RILUZOLE OF ENTRY OF CALCIUM EVOKED BY NMDA AND VERATRIDINE IN RAT CULTURED GRANULE CELLS - EVIDENCE FOR A DUAL MECHANISM OF ACTION [J].

HUBERT, JP ;

DELUMEAU, JC ;

GLOWINSKI, J ;

PREMONT, J ;

DOBLE, A .

BRITISH JOURNAL OF PHARMACOLOGY, 1994, 113 (01) :261-267

[8] Dose-ranging study of riluzole in amyotrophic lateral sclerosis [J].

Lacomblez, L ;

Bensimon, G ;

Leigh, PN ;

Guillet, P ;

Meininger, V .

LANCET, 1996, 347 (9013) :1425-1431

[9] BRAIN GLUTAMATE DEFICIENCY IN AMYOTROPHIC-LATERAL-SCLEROSIS [J].

PERRY, TL ;

HANSEN, S ;

JONES, K .

NEUROLOGY, 1987, 37 (12) :1845-1848

[10] THE NEUROEXCITOTOXIC AMINO-ACIDS GLUTAMATE AND ASPARTATE ARE ALTERED IN THE SPINAL-CORD AND BRAIN IN AMYOTROPHIC LATERAL SCLEROSIS [J].

PLAITAKIS, A ;

CONSTANTAKAKIS, E ;

SMITH, J .

ANNALS OF NEUROLOGY, 1988, 24 (03) :446-449

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