Diverse developmental programs of Xenopus laevis metamorphosis are inhibited by a dominant negative thyroid hormone receptor

被引：143

作者：

Schreiber, AM ^{[1
]}

Das, B ^{[1
]}

Huang, HC ^{[1
]}

Marsh-Armstrong, N ^{[1
]}

Brown, DD ^{[1
]}

机构：

[1] Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 19期

关键词：

D O I：

10.1073/pnas.191361698

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Metamorphosis of anuran tadpoles is controlled by thyroid hormone (TH). Here we demonstrate that transgenic Xenopus laevis tadpoles expressing a dominant negative form of TH receptor-a are resistant to a wide variety of the metamorphic changes induced by TH. This result confirms that TH receptors mediate both early and late developmental programs of metamorphosis as diverse as growth in the brain, limb buds, nose and Meckel's cartilage, remodeling of the intestine, and death and resorption of the gills and tail.

引用

页码：10739 / 10744

页数：6

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