Adiponectin inhibits the binding of low-density lipoprotein to biglycan, a vascular proteoglycan

被引：13

作者：

Kobayashi, K ^{[1
]}

Inoguchi, T ^{[1
]}

Sonoda, N ^{[1
]}

Sekiguchi, N ^{[1
]}

Nawata, H ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulat Sci, Fukuoka 812, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 335卷 / 01期

关键词：

adiponectin; biglycan; extracellular matrices; proteoglycan; LDL retention; apolipoprotein B; full-length; globular; atherosclerosis; solid-phase plate assays;

D O I：

10.1016/j.bbrc.2005.07.048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to test the possibility that adiponectin has an antiatherogenic effect through the inhibition of LDL binding to proteoglycans, an initial event in atherogenesis. Both full-length and globular adiponectin inhibited LDL binding in a dose-dependent manner. Both types of adiponectin bound to biglycan in a dose-dependent manner. Immunoprecipitation and immunoblotting analysis showed interaction of full-length adiponectin with LDL. Pretreatment of biglycan with globular adiponectin prior to LDL addition diminished the inhibitory effect, while pretreatment with full-length adiponectin retained the effect. This is a new antiatherogenic property that appears independent of the receptor-mediated hormonal action of adiponectin. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：66 / 70

页数：5

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