Gestational trophoblastic disease

被引：748

作者：

Seckl, Michael J. ^{[1
]}

Sebire, Neil J. ^{[2
]}

Berkowitz, Ross S. ^{[3
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Charing Cross Hosp Campus, Charing Cross Gestat Trophoblast Dis Ctr, Dept Canc Med, London W6 8RF, England

[2] Univ London Imperial Coll Sci Technol & Med, Charing Cross Hosp Campus, Charing Cross Gestat Trophoblast Dis Ctr, Dept Histopathol, London W6 8RF, England

[3] Harvard Univ, Brigham & Womens Hosp, Dana Farber Canc Inst,Div Gynecol Oncol,Sch Med, Dept Obstet & Gynecol,New England Trophoblast Dis, Boston, MA 02115 USA

来源：

LANCET | 2010年 / 376卷 / 9742期

关键词：

HUMAN CHORIONIC-GONADOTROPIN; COMPLETE HYDATIDIFORM MOLE; POLYMERASE CHAIN-REACTION; RETROSPECTIVE COHORT SURVEY; REPEAT UTERINE EVACUATION; HIGH-DOSE CHEMOTHERAPY; FREE BETA-SUBUNIT; SUBSEQUENT PREGNANCY; ACTINOMYCIN-D; VINCRISTINE CHEMOTHERAPY;

D O I：

10.1016/S0140-6736(10)60280-2

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Gestational trophoblastic disease encompasses a range of pregnancy-related disorders, consisting of the premalignant disorders of complete and partial hydatidiform mole, and the malignant disorders of invasive mole, choriocarcinoma, and the rare placental-site trophoblastic tumour. These malignant forms are termed gestational trophoblastic tumours or neoplasia. Improvements in management and follow-up protocols mean that overall cure rates can exceed 98% with fertility retention, whereas most women would have died from malignant disease 60 years ago This success can be explained by the development of effective treatments, the use of human chorionic gonadotropin as a biomarker, and centralisation of care. We summarise strategies for management of gestational trophoblastic disease and address some of the controversies and future research directions.

引用

页码：717 / 729

页数：13

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