Leptin in immunology

被引：450

作者：

Matarese, G

Moschos, S

Mantzoros, CS

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Internal Med,Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

[2] CNR, IEOS, Ist Endocrinol & Oncol Sperimentale, Grp Immunoendocrinol, I-80125 Naples, Italy

[3] Pittsburgh Canc Inst, Dept Med, Div Hematol Oncol, Pittsburgh, PA 15232 USA

来源：

JOURNAL OF IMMUNOLOGY | 2005年 / 174卷 / 06期

关键词：

D O I：

10.4049/jimmunol.174.6.3137

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Leptin is an adipokine which conveys information on energy availability. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. As a cytokine, Leptin also affects thymic homeostasis and, similar to other proinflammatory cytokines, leptin promotes Th1 cell differentiation and cytokine production. We review herein recent advances on, the role of leptin in the pathophysiology of immune responses.

引用

页码：3137 / 3142

页数：6

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