SH2B1-The Adaptor Protein that Could

被引：4

作者：

Chua, Streamson, Jr. ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA

来源：

ENDOCRINOLOGY | 2010年 / 151卷 / 09期

关键词：

LEPTIN-RECEPTOR; GLUCOSE-HOMEOSTASIS; NEURONAL SH2B1; ACTIVATION; SH2-B; KINASE; PHOSPHORYLATION; JAK2; MICE; IDENTIFICATION;

D O I：

10.1210/en.2010-0572

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

引用

页码：4100 / 4102

页数：3

共 21 条

[1]

Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers [J].

Bahrenberg, G ;

Behrmann, I ;

Barthel, A ;

Hekerman, P ;

Heinrich, PC ;

Joost, HG ;

Becker, W .

MOLECULAR ENDOCRINOLOGY, 2002, 16 (04) :859-872

[2]

Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers [J].

Couturier, C ;

Jockers, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (29) :26604-26611

[3]

The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells [J].

Cross, MJ ;

Lu, LG ;

Magnusson, P ;

Nyqvist, D ;

Holmqvist, K ;

Welsh, M ;

Claesson-Welsh, L .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (08) :2881-2893

[4]

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes [J].

de Luca, C ;

Kowalski, TJ ;

Zhang, YY ;

Elmquist, JK ;

Lee, C ;

Kilimann, MW ;

Ludwig, T ;

Liu, SM ;

Chua, SC .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (12) :3484-3493

[5]

SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin [J].

Duan, CJ ;

Li, MH ;

Rui, LY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (42) :43684-43691

[6]

CLONING AND CHARACTERIZATION OF LNK, A SIGNAL-TRANSDUCTION PROTEIN THAT LINKS T-CELL RECEPTOR ACTIVATION SIGNAL TO PHOSPHOLIPASE C-GAMMA(1), GRB2, AND PHOSPHATIDYLINOSITOL 3-KINASE [J].

HUANG, XM ;

LI, YJ ;

TANAKA, K ;

MOORE, KG ;

HAYASHI, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) :11618-11622

[7]

Leptin receptor modulation of adiposity and fertility [J].

Israel, Davelene ;

Chua, Streamson, Jr. .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2010, 21 (01) :10-16

[8]

SH2-Bα is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase [J].

Kotani, K ;

Wilden, P ;

Pillay, TS .

BIOCHEMICAL JOURNAL, 1998, 335 :103-109

[9]

Transgenic complementation of leptin-receptor deficiency - I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene [J].

Kowalski, TJ ;

Liu, SM ;

Leibel, RL ;

Chua, SC .

DIABETES, 2001, 50 (02) :425-435

[10]

Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state [J].

Kurzer, Jason H. ;

Saharinen, Pipsa ;

Silvennoinen, Olli ;

Carter-Su, Christin .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (17) :6381-6394

← 1 2 3 →