Pancreatitis treated with didanosine and tenofovir disoproxil fumarate

被引:35
作者
Blanchard, JN
Wohlfeiler, M
Canas, A
King, K
Lonergan, JT
机构
[1] Univ Calif San Diego, San Diego Med Ctr, Div Gen Internal Med, San Diego, CA 92103 USA
[2] Mercy Hosp, Dept Internal Med, Miami Beach, FL USA
关键词
D O I
10.1086/376991
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Pancreatitis occurs in up to 7% of patients infected with human immunodeficiency virus who are treated with standard doses of didanosine. Tenofovir disoproxil fumarate increases the plasma levels of didanosine and, thus, the combination of these agents may increase the risk of pancreatitis. Four cases of pancreatitis that occurred during administration of this drug combination are examined, including 1 that resulted in death.
引用
收藏
页码:E57 / E62
页数:6
相关论文
共 29 条
  • [1] Low risk of pancreatitis in HIV-infected patients on hydroxyurea plus didanosine
    Barreiro, P
    Soriano, V
    Valencia, E
    Díaz, B
    González-Lahoz, J
    [J]. AIDS, 2001, 15 (18) : 2469 - 2470
  • [2] Assessment of mitochondrial toxicity in human cells treated with tenofovir: Comparison with other nucleoside reverse transcriptase inhibitors
    Birkus, G
    Hitchcock, MJM
    Cihlar, T
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (03) : 716 - 723
  • [3] BOXWELL D, 2003, 10 C RETR OPP INF BO, P333
  • [4] Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway
    Brinkman, K
    ter Hofstede, HJM
    Burger, DM
    Smeitinkt, JAM
    Koopmans, PP
    [J]. AIDS, 1998, 12 (14) : 1735 - 1744
  • [5] ACUTE-PANCREATITIS IN HIV-SEROPOSITIVE PATIENTS - A CASE-CONTROL STUDY OF 44 PATIENTS
    CAPPELL, MS
    MARKS, M
    [J]. AMERICAN JOURNAL OF MEDICINE, 1995, 98 (03) : 243 - 248
  • [6] 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity
    Daluge, SM
    Good, SS
    Faletto, MB
    Miller, WH
    StClair, MH
    Boone, LR
    Tisdale, M
    Parry, NR
    Reardon, JE
    Dornsife, RE
    Averett, DR
    Krenitsky, TA
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) : 1082 - 1093
  • [7] Acute pancreatitis in human immunodeficiency virus-infected patients: A review
    Dassopoulos, T
    Ehrenpreis, ED
    [J]. AMERICAN JOURNAL OF MEDICINE, 1999, 107 (01) : 78 - 84
  • [8] Dutta SK, 1997, AM J GASTROENTEROL, V92, P2044
  • [9] FLAHERTY J, 2001, 41 INT C ANT AG CHEM, P329
  • [10] Direct analysis of mitochondrial toxicity of antiretroviral drugs
    Foli, A
    Benvenuto, F
    Piccinini, G
    Bareggi, A
    Cossarizza, A
    Lisziewicz, J
    Lori, F
    [J]. AIDS, 2001, 15 (13) : 1687 - 1694