NF-κB inducing kinase: A key regulator in the immune system and in cancer

被引：143

作者：

Thu, Yee Mon ^{[1
]}

Richmond, Ann ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Vet Affairs, Med Ctr, Dept Canc Biol,Sch Med, Nashville, TN 37232 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2010年 / 21卷 / 04期

关键词：

NF-kappa B inducing kinase (NIK); NF-kappa B; IKK; Canonical pathway; Non-canonical pathway; LYMPHOTOXIN-BETA-RECEPTOR; ALPHA-DEPENDENT APOPTOSIS; SECONDARY LYMPHOID ORGANS; ALYMPHOPLASIA ALY MICE; SIGNALING PATHWAY; IKK-ALPHA; CONSTITUTIVE ACTIVATION; CELL-DIFFERENTIATION; MULTIPLE-MYELOMA; NF-KAPPA-B2; P100;

D O I：

10.1016/j.cytogfr.2010.06.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

NF-kappa B inducing kinase (NIK) is a kinase that activates the canonical and non-canonical NF-kappa B pathways to control transcriptional expression of certain proteins such as cytokines, chemokines and NF-kappa B signaling molecules. Many advances have been made in understanding the molecular mechanisms by which the stability of NIK is regulated to affect downstream signaling. Genetic mouse models suggest that NIK plays an essential role in the regulation of the immune system as well as in the bone microenvironment. Increasing evidence links NIK to the tumorigenesis of hematological cancers, such as multiple myeloma, and solid tumors, such as pancreatic carcinoma and melanoma. Understanding the mechanism by which NIK is de-regulated will potentially provide therapeutic options for certain diseases such as autoimmunity and cancer. Published by Elsevier Ltd.

引用

页码：213 / 226

页数：14

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