Ub surprised: Viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates

被引：12

作者：

Arguello, Meztli D. ^{[1
]}

Hiscott, John ^{[1
,2
,3
]}

机构：

[1] McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada

[2] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3A 2B4, Canada

[3] McGill Univ, Dept Expt Med, Montreal, PQ H3A 2B4, Canada

来源：

CELL HOST & MICROBE | 2007年 / 2卷 / 06期

关键词：

D O I：

10.1016/j.chom.2007.11.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Conjugation of ubiquitin regulates multiple pathways, including the signaling cascades leading to antiviral immunity. Similarly, the ubiquitin-like peptide ISG15 mediates the antiviral response to certain viruses. In this issue of Cell Host & Microbe, Frias-Staheli and colleagues demonstrate that research on viral proteases of certain nairoviruses and arteriviruses reveals the presence of ovarian tumor domain-containing sequences that act as general deubiquitinases and deISGylases and increase viral replication by inhibiting the antiviral response mediated by ISG15.

引用

页码：367 / 369

页数：3

共 10 条

[1] Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses [J].

Frias-Staheli, Natalia ;

Giannakopoulos, Nadia V. ;

Kikkert, Marjolein ;

Taylor, Shannon L. ;

Bridgen, Anne ;

Paragas, Jason ;

Richt, Juergen A. ;

Rowland, Raymond R. ;

Schmaljohn, Connie S. ;

Lenschow, Deborah J. ;

Snijder, Eric J. ;

Garcia-Sastre, Adolfo ;

Virgin, Herbert Whiting .

CELL HOST & MICROBE, 2007, 2 (06) :404-416

[2]

Hacker H., Sci. Signal, DOI DOI 10.1126/STKE.3572006RE13

[3] Triggering the innate antiviral response through IRF-3 activation [J].

Hiscott, John .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (21) :15325-15329

[4]

KAYAGAKI N, 2007, SCIENCE

[5] IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses [J].

Lenschow, Deborah J. ;

Lai, Caroline ;

Frias-Staheli, Natalia ;

Giannakopoulos, Nadia V. ;

Lutz, Andrew ;

Wolff, Thorsten ;

Osiak, Anna ;

Levine, Beth ;

Schmidt, Robert E. ;

Garcia-Sastre, Adolfo ;

Leib, David A. ;

Pekosz, Andrew ;

Knobeloch, Klaus-Peter ;

Horak, Ivan ;

Whiting Virgin, Herbert .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (04) :1371-1376

[6] Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20 [J].

Lin, RT ;

Yang, L ;

Nakhaei, P ;

Sun, Q ;

Sharif-Askari, E ;

Julkunen, I ;

Hiscott, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (04) :2095-2103

[7] Immunity by ubiquitylation: A reversible process of modification [J].

Liu, YC ;

Penninger, J ;

Karin, M .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (12) :941-952

[8] Antiviral innate immunity pathways [J].

Seth, RB ;

Sun, LJ ;

Chen, ZJJ .

CELL RESEARCH, 2006, 16 (02) :141-147

[9] De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling [J].

Wertz, IE ;

O'Rourke, KM ;

Zhou, HL ;

Eby, M ;

Aravind, L ;

Seshagiri, S ;

Wu, P ;

Wiesmann, C ;

Baker, R ;

Boone, DL ;

Ma, A ;

Koonin, EV ;

Dixit, VM .

NATURE, 2004, 430 (7000) :694-699

[10] Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein [J].

Yuan, WM ;

Krug, RM .

EMBO JOURNAL, 2001, 20 (03) :362-371

← 1 →