Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding

被引：286

作者：

Xue, Yali ^{[1
]}

Prado-Martinez, Javier ^{[2
]}

Sudmant, Peter H. ^{[3
]}

Narasimhan, Vagheesh ^{[1
,4
]}

Ayub, Qasim ^{[1
]}

Szpak, Michal ^{[1
]}

Frandsen, Peter ^{[5
]}

Chen, Yuan ^{[1
]}

Yngvadottir, Bryndis ^{[1
]}

Cooper, David N. ^{[6
]}

de Manuel, Marc ^{[2
]}

Hernandez-Rodriguez, Jessica ^{[2
]}

Lobon, Irene ^{[2
]}

Siegismund, Hans R. ^{[5
]}

Pagani, Luca ^{[1
,7
]}

Quail, Michael A. ^{[1
]}

Hvilsom, Christina ^{[8
]}

Mudakikwa, Antoine ^{[9
]}

Eichler, Evan E. ^{[3
,10
]}

Cranfield, Michael R. ^{[11
]}

Marques-Bonet, Tomas ^{[2
,12
]}

Tyler-Smith, Chris ^{[1
]}

Scally, Aylwyn ^{[13
]}

机构：

[1] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England

[2] Inst Biol Evolut CSIC UPF, Barcelona 08003, Catalonia, Spain

[3] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

[4] Univ Cambridge, Dept Appl Math & Theoret Phys, Cambridge CB3 0WA, England

[5] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen N, Denmark

[6] Cardiff Univ, Inst Med Genet, Cardiff CF14 4XN, S Glam, Wales

[7] Univ Bologna, Dept Biol Geol & Environm Sci, I-40134 Bologna, Italy

[8] Copenhagen Zoo, Res & Conservat, DK-2000 Frederiksberg, Denmark

[9] Rwanda Dev Board, Kigali, Rwanda

[10] Howard Hughes Med Inst, Seattle, WA USA

[11] Univ Calif Davis, Karen C Drayer Wildlife Hlth Ctr, Gorilla Doctors, Davis, CA 95616 USA

[12] Ctr Nacl Anal Genom, Barcelona 08028, Spain

[13] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

来源：

SCIENCE | 2015年 / 348卷 / 6231期

基金：

欧洲研究理事会; 英国惠康基金;

关键词：

DIVERSITY;

D O I：

10.1126/science.aaa3952

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mountain gorillas are an endangered great ape subspecies and a prominent focus for conservation, yet we know little about their genomic diversity and evolutionary past. We sequenced whole genomes from multiple wild individuals and compared the genomes of all four Gorilla subspecies. We found that the two eastern subspecies have experienced a prolonged population decline over the past 100,000 years, resulting in very low genetic diversity and an increased overall burden of deleterious variation. A further recent decline in the mountain gorilla population has led to extensive inbreeding, such that individuals are typically homozygous at 34% of their sequence, leading to the purging of severely deleterious recessive mutations from the population. We discuss the causes of their decline and the consequences for their future survival.

引用

页码：242 / 245

页数：4

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