Cdk6-Dependent Regulation of G1 Length Controls Adult Neurogenesis

被引：54

作者：

Beukelaers, Pierre ^{[1
]}

Vandenbosch, Renaud ^{[1
]}

Caron, Nicolas ^{[1
]}

Nguyen, Laurent ^{[1
]}

Belachew, Shibeshih ^{[2
]}

Moonen, Gustave ^{[1
,2
]}

Kiyokawa, Hiroaki ^{[3
]}

Barbacid, Mariano ^{[4
]}

Santamaria, David ^{[4
]}

Malgrange, Brigitte ^{[1
]}

机构：

[1] Univ Liege, GIGA Neurosci, B-4000 Liege, Belgium

[2] CHU Sart Tilman, Dept Neurol, B-4000 Liege, Belgium

[3] Northwestern Univ, Dept Mol Pharmacol & Biol Chem, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Ctr Nacl Invest Oncol, Mol Oncol Programme, Madrid, Spain

来源：

STEM CELLS | 2011年 / 29卷 / 04期

关键词：

Adult neurogenesis; Cell cycle; G(1) length; Cyclin-dependent kinase; Dentate gyrus; Subventricular zone; NEURAL STEM-CELLS; CYCLIN-DEPENDENT KINASES; DENTATE GYRUS; SUBVENTRICULAR ZONE; HIPPOCAMPAL NEUROGENESIS; PROGENITOR CELLS; SELF-RENEWAL; BORN NEURONS; PROLIFERATION; BRAIN;

D O I：

10.1002/stem.616

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

The presence of neurogenic precursors in the adult mammalian brain is now widely accepted, but the mechanisms coupling their proliferation with the onset of neuronal differentiation remain unknown. Here, we unravel the major contribution of the G(1) regulator cyclin-dependent kinase 6 (Cdk6) to adult neurogenesis. We found that Cdk6 was essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Specifically, Cdk6 deficiency prevents the expansion of neuronally committed precursors by lengthening G(1) phase duration, reducing concomitantly the production of newborn neurons. Altogether, our data support G(1) length as an essential regulator of the switch between proliferation and neuronal differentiation in the adult brain and Cdk6 as one intrinsic key molecular regulator of this process. STEM CELLS 2011; 29: 713-724

引用

页码：713 / 724

页数：12

共 73 条

[1]

Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4) [J].