Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism

被引：70

作者：

Yu, KF

Lieber, MR

机构：

[1] Norris Comprehens Canc Ctr, Dept Pathol, Los Angeles, CA 90033 USA

[2] Norris Comprehens Canc Ctr, Dept Biochem & Mol Biol, Los Angeles, CA 90033 USA

[3] Norris Comprehens Canc Ctr, Dept Mol Microbiol, Los Angeles, CA 90033 USA

[4] Norris Comprehens Canc Ctr, Dept Immunol, Los Angeles, CA 90033 USA

[5] Norris Comprehens Canc Ctr, Dept Biol Sci, Los Angeles, CA 90033 USA

来源：

DNA REPAIR | 2003年 / 2卷 / 11期

关键词：

Non-B form DNA; R-loop; deaminase; abasic site; immunoglobulin gene rearrangement; isotype switching; uracil glycosylase;

D O I：

10.1016/j.dnarep.2003.08.010

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Class switch recombination is the gene rearrangement process by which our B lymphocytes change from IgM production to IgG, IgA, or IgE. Unlike the well-characterized V(D)J recombination, the mechanism of class switch recombination has been largely enigmatic until very recent progress has begun to shed light on this gene rearrangement process. Progress has been made on the enzymes involved in leading to the DNA cleavage events and on identifying the unusual DNA structures that those enzymes recognize. (C) 2003 Elsevier B.V. All rights reserved.

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收藏

页码：1163 / 1174

页数：12

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