β-Arrestins: multifunctional signaling adaptors in type 2 diabetes

被引：15

作者：

Feng, Xiaotao ^{[1
]}

Wang, Wenjian ^{[1
,2
]}

Liu, Jibo ^{[1
]}

Liu, Yi ^{[1
]}

机构：

[1] Fudan Univ, Huashan Hosp, Inst Chinese Integrat Med, Shanghai 200040, Peoples R China

[2] Shanghai Tradit Chinese Med Univ, Yueyang Integrat Med Hosp, Shanghai Acad Tradit Chinese Med, Inst Integrated Med Clin, Shanghai 200040, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2011年 / 38卷 / 04期

关键词：

beta-Arrestin; Signal transduction; Insulin resistance; Lipotoxicity; Type; 2; diabetes; NF-KAPPA-B; INDUCED INSULIN-RESISTANCE; GLUCAGON-LIKE PEPTIDE-1; FREE FATTY-ACID; PROTEIN-COUPLED RECEPTORS; SKELETAL-MUSCLE CELLS; CRYSTAL-STRUCTURE; 3T3-L1; ADIPOCYTES; IKK-BETA; PHOTORECEPTOR-MEMBRANES;

D O I：

10.1007/s11033-010-0389-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

beta-Arrestins are not only well-known negative regulators of G protein-coupled receptor (GPCR) signaling, but also important adaptors in modulating the strength and duration of cellular signaling by scaffolding and interacting with a lot of cytoplasmic proteins. While beta-arrestins are rather well described signal-mediated molecules, they are not generally associated with insulin signaling. But recent work has confirmed the difference from original thought. The current review aims to explore the emerging roles for beta-arrestins in regulating insulin action, inflammatory signal pathway and other cellular signaling which are associated with type 2 diabetes.

引用

页码：2517 / 2528

页数：12

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