Immunohistochemical expression of cyclooxygenase-2 in canine ovarian carcinomas

被引：10

作者：

Borzacchiello, G.

Russo, V.

Russo, M.

机构：

[1] Univ Naples Federico II, Fac Vet Med, Dept Pathol & Anim Hlth, Gen Pathol & Anat Pathol Div, I-80137 Naples, Italy

[2] Univ Naples Federico II, Fac Vet Med, Dept Vet Clin Sci, Obstet & Gynaecol Div, I-80137 Naples, Italy

来源：

JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE | 2007年 / 54卷 / 05期

关键词：

URINARY-BLADDER; CANCER PREVENTION; CELL CARCINOMA; TUMORS; DOGS; CHEMOTHERAPY; INHIBITOR; PIROXICAM; MODEL;

D O I：

10.1111/j.1439-0442.2007.00934.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

090604 [动物药学];

摘要：

Ovarian turnours among domestic animals are frequently encountered in bitch. Cyclooxygenase-2 (COX-2) expression has been evaluated in different kind of canine primary epithelial neoplasms. Eleven canine ovarian carcinomas and two normal samples were evaluated immunohistochemically for COX-2 expression. Nine of 11 carcinoma samples (81 %) expressed COX-2 enzyme isoform. The immunoreactivity was intracytoplasmically recorded and the intensity ranged from faint to strong. Our results show that COX-2 is expressed in canine ovarian carcinoma, suggesting a potential role of COX-2 in canine ovarian carcinogenesis.

引用

页码：247 / 249

页数：3

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