GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons

被引：72

作者：

Young, Stephen G.

Davies, Brandon S. J.

Fong, Loren G.

Gin, Peter

Weinstein, Michael M.

Bensadoun, Andre

Beigneux, Anne P.

机构：

[1] Univ Calif Los Angeles, Dept Med, Div Cardiol, David Geffen Sch Med, Los Angeles, CA 90095 USA

[2] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 2007年 / 18卷 / 04期

关键词：

chylomicronemia; glycosylphosphatidylinositol-anchored proteins; hypertriglyceridemia; lipoprotein lipase;

D O I：

10.1097/MOL.0b013e3281527914

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chylomicronemia in Gpihbp1-deficient mice, the fact that GPIHBP1 is located within the lumen of capillaries, and the fact that GPIHBP1 binds lipoprotein lipase and chylomicrons suggest that GPIHBP1 is a key platform for the lipolytic processing of triglyceride-rich lipoproteins.

引用

收藏

页码：389 / 396

页数：8

相关论文

共 53 条

[1] Identification of scavenger receptor SR-BI as a high density lipoprotein receptor [J].

Acton, S ;

Rigotti, A ;

Landschulz, KT ;

Xu, SZ ;

Hobbs, HH ;

Krieger, M .

SCIENCE, 1996, 271 (5248) :518-520

[2]

ACTON SL, 1994, J BIOL CHEM, V269, P21003

[3] Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons [J].

Beigneux, Anne P. ;

Davies, Brandon S. J. ;

Gin, Peter ;

Weinstein, Michael M. ;

Farber, Emily ;

Qiao, Xin ;

Peale, Franklin ;

Bunting, Stuart ;

Walzem, Rosemary L. ;

Wong, Jinny S. ;

Blaner, William S. ;

Ding, Zhi-Ming ;

Melford, Kristan ;

Wongsiriroj, Nuttaporn ;

Shu, Xiao ;

de Sauvage, Fred ;

Ryan, Robert O. ;

Fong, Loren G. ;

Bensadoun, Andre ;

Young, Stephen G. .

CELL METABOLISM, 2007, 5 (04) :279-291

[4] ACTIVATION OF LIPOPROTEIN-LIPASE BY APOLIPOPROTEIN-CII - DEMONSTRATION OF AN EFFECT OF THE ACTIVATOR ON THE BINDING OF THE ENZYME TO MILK-FAT GLOBULES [J].

BENGTSSON, G ;

OLIVECRONA, T .

FEBS LETTERS, 1982, 147 (02) :183-187

[5]

BENGTSSON G, 1980, EUR J BIOCHEM, V106, P549, DOI 10.1111/j.1432-1033.1980.tb04602.x

[6] APOLIPOPROTEIN-CII ENHANCES HYDROLYSIS OF MONOGLYCERIDES BY LIPOPROTEIN-LIPASE, BUT THE EFFECT IS ABOLISHED BY FATTY-ACIDS [J].

BENGTSSON, G ;

OLIVECRONA, T .

FEBS LETTERS, 1979, 106 (02) :345-348

[7]

BENSADOUN A, 1991, ANNU REV NUTR, V11, P217, DOI 10.1146/annurev.nu.11.070191.001245

[8]

BENZEEV O, 1992, J BIOL CHEM, V267, P6219

[9] Down-regulation of adipose tissue lipoprotein lipase during fasting requires that a gene, separate from the lipase gene, is switched on [J].

Bergö, M ;

Wu, GS ;

Ruge, T ;

Olivecrona, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (14) :11927-11932

[10]

BERRYMAN DE, 1993, J BIOL CHEM, V268, P3272

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